. "Current Opinion in Microbiology" . "3"^^ . "7"^^ . . "[C635E808BAD4]" . "RIV/61388971:_____/06:00040412" . "Bordetella adenylate cyclase toxin: a swift saboteur of host defense"@en . "467294" . "3"^^ . "\u0160ebo, Peter" . . "9" . . . . . "Publikace %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 je p\u0159ehledn\u00E9 review, kter\u00E9 shrnuje sou\u010Dasn\u00E9 znalosti o struktu\u0159e adenyl\u00E1tcykl\u00E1zov\u00E9ho toxinu bakterie Bordetella pertussis a jeho \u00FA\u010Dinc\u00EDch na bu\u0148ky imunitn\u00EDho syst\u00E9mu a bu\u0148ky respira\u010Dn\u00EDho epitelu. Ukazuje se, \u017Ee adenyl\u00E1tcykl\u00E1zov\u00FD toxin (CyaA) napom\u00E1h\u00E1 nav\u00E1z\u00E1n\u00ED bakterie na \u0159asinkov\u00E9 bu\u0148ky respira\u010Dn\u00EDho epitelu a indukuje sekreci proz\u00E1n\u011Btliv\u00E9ho cytokinu IL-6 z t\u011Bchto bun\u011Bk. V p\u0159\u00EDpad\u011B bun\u011Bk imunitn\u00EDho syst\u00E9mu CyaA po vazb\u011B na receptorovou molekulu CD11b/CD18 pronik\u00E1 do cytozolu, kde katalyzuje neregulovanou p\u0159em\u011Bnu ATP na cAMP. To vede, krom\u011B inhibice imunitn\u00EDch mechanizm\u016F nam\u00ED\u0159en\u00FDch proti infekci, k \u010D\u00E1ste\u010Dn\u00E9 maturaci dendritick\u00FDch bun\u011Bk, a tak pravd\u011Bpodobn\u011B k navozen\u00ED stavu tolerance v\u016F\u010Di bakteri\u00EDm v m\u00EDst\u011B infekce"@cs . . "Adenyl\u00E1tcykl\u00E1zov\u00FD toxin bakterie Bordetella: pohotov\u00FD sabot\u00E9r imunitn\u00EDho syst\u00E9mu hostitele"@cs . "cyaa; scanning electron microscopy; cyclase toxin"@en . "The review %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 summarizes recent findings about structure of adenylate cyclase toxin of Bordetella pertussis and its effects on both immune and respiratory epithelial cells. It has been shown that interaction of adenylate cyclase toxin (CyaA) with epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro-inflammatory cytokine interleukin, IL-6. Myeloid phagocytes, attracted to the site of infection are the target of freshly secreted CyaA that binds to CD11b/CD18, penetrates cells and promptly suppresses their bactericidal functions by converting cellular ATP to cAMP. Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen" . "P(1M0506), P(IAA5020406), Z(AV0Z50200510)" . "1369-5274" . . "RIV/61388971:_____/06:00040412!RIV07-MSM-61388971" . "NL - Nizozemsko" . . . "1;7" . "Adenyl\u00E1tcykl\u00E1zov\u00FD toxin bakterie Bordetella: pohotov\u00FD sabot\u00E9r imunitn\u00EDho syst\u00E9mu hostitele"@cs . . "Bordetella adenylate cyclase toxin: a swift saboteur of host defense"@en . "The review %22Bordetella adenylate cyclase toxin: a swift saboteur of host defense%22 summarizes recent findings about structure of adenylate cyclase toxin of Bordetella pertussis and its effects on both immune and respiratory epithelial cells. It has been shown that interaction of adenylate cyclase toxin (CyaA) with epithelial cells aids adhesion of Bordetella to ciliated mucosa and induces production of the pro-inflammatory cytokine interleukin, IL-6. Myeloid phagocytes, attracted to the site of infection are the target of freshly secreted CyaA that binds to CD11b/CD18, penetrates cells and promptly suppresses their bactericidal functions by converting cellular ATP to cAMP. Such uncontrolled cAMP signaling can also drive CD11b-expressing immature dendritic cells into a semi-mature state, possibly hijacking them to shape the local adaptive immune response towards tolerance of the pathogen"@en . "Bordetella adenylate cyclase toxin: a swift saboteur of host defense" . . . . . "Kamanov\u00E1, Jana" . . . "Bordetella adenylate cyclase toxin: a swift saboteur of host defense" . . "Vojtov\u00E1, Jana" . "-" . .