"US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "44" . "-" . "Maier, E." . . "P(1M0506), P(IAA5020406), Z(AV0Z50200510)" . "511341" . "0006-2960" . . . . "12766;12759" . "Pr\u00E1ce ukazuje, \u017Ee jedin\u00E1 acylace jak na lysinu 860 tak na lysinu 983 posta\u010Duje pro t\u011Bsnou interakci ACT s integrinov\u00FDm receptorem CD11b/CD18. Tato funk\u010Dn\u00ED redundance dvou acyla\u010Dn\u00EDch m\u00EDst nem\u00E1 z\u0159ejm\u00FD d\u016Fvod, nicm\u00E9n\u011B umo\u017E\u0148uje pr\u016Fnik toxinu do bun\u011Bk p\u0159es plasmatickou membr\u00E1nu"@cs . "Knapp, O." . "The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown to depend on post-translational activation of proCyaA to CyaA by covalent palmitoylation of the internal Lys983 residue (K983). CyaA, however, harbors a second RTX acylation site at residue Lys860 (K860), and the role of K860 acylation in toxin activity is unclear"@en . "Benz, R." . . "Acylace lysinov\u00E9ho zbytku 860 umo\u017E\u0148uje pevnou vazbu a cytotoxickou aktivitu adenyl\u00E1t-cyklazov\u00E9ho toxinu bakt\u00E9rie Bordetella pertussis na bu\u0148k\u00E1ch exprimunj\u00EDc\u00EDch CD11b"@cs . . "3"^^ . . "Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells" . "The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown to depend on post-translational activation of proCyaA to CyaA by covalent palmitoylation of the internal Lys983 residue (K983). CyaA, however, harbors a second RTX acylation site at residue Lys860 (K860), and the role of K860 acylation in toxin activity is unclear" . "\u0160ebo, Peter" . . . "[60E0FCBB0C55]" . "Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells"@en . . "9"^^ . . "Ma\u0161\u00EDn, Ji\u0159\u00ED" . . "7"^^ . "RIV/61388971:_____/05:00022198!RIV06-AV0-61388971" . "Leclerc, C." . "Basler, Marek" . . . "Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells"@en . "El-Azami-El-Idrissi, M." . "RIV/61388971:_____/05:00022198" . . "Biochemistry" . "Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD1 1b-Expressing Cells" . . . . "Acylace lysinov\u00E9ho zbytku 860 umo\u017E\u0148uje pevnou vazbu a cytotoxickou aktivitu adenyl\u00E1t-cyklazov\u00E9ho toxinu bakt\u00E9rie Bordetella pertussis na bu\u0148k\u00E1ch exprimunj\u00EDc\u00EDch CD11b"@cs . "lysine 860; bordetella"@en . . "Konop\u00E1sek, I." .