"Shared features and analysis of lincosamide and anthramycin antibiotic gene clusters"@en . . "Janata, Ji\u0159\u00ED" . . "Kopeck\u00FD, Jan" . . . "Brno" . . . "586074" . "1"^^ . "Anal\u00FDza genov\u00E9ho clusteru anthramycinov\u00FDch a lincosamidov\u00FDch antibiotik"@cs . . . "Ve shluku gen\u016F k\u00F3duj\u00EDc\u00EDch biosynt\u00E9zu linkomycinu bylo zji\u0161t\u011Bno 27 otev\u0159en\u00FDch \u010Dtec\u00EDch r\u00E1mc\u016F s biosyntetickou \u010Di regula\u010Dn\u00ED funkc\u00ED a 3 rezisten\u010Dn\u00ED geny. Ze srovn\u00E1n\u00ED chemick\u00E9 struktury linkomycinu a celesticetinu vypl\u00FDv\u00E1, \u017Ee v biosyntetick\u00E9 dr\u00E1ze chyb\u00ED dr\u00E1ha vedouc\u00ED k propylprolinu a prolin je p\u0159\u00EDmo substr\u00E1tem kondenza\u010Dn\u00ED reakce. \u010C\u00E1st biosyntetick\u00E9 dr\u00E1hy zahrnuj\u00EDc\u00ED p\u0159em\u011Bnu L-tyrosinu na propyl-L-prolin by m\u011Bla b\u00FDt p\u0159\u00EDtomna v biosyntetick\u00E9 dr\u00E1ze funk\u010Dn\u011B odli\u0161n\u00FDch antramycinov\u00FDch antibiotik. Byla zji\u0161\u0165ov\u00E1no rozvr\u017Een\u00ED genu linkomycinov\u00E9ho biosyntetick\u00E9ho shluku do transkrip\u010Dn\u00EDch jednotek. D\u00E1le byla na z\u00E1klad\u011B sekvence tohoto shluku navr\u017Eena sada sond, pomoc\u00ED nich\u017E byly vyhl\u00E9d\u00E1v\u00E1ny analogy gen\u016F v producentech celesticetinu Streptomyces caelestis a antramycin\u016F Streptomyces refuineus, Streptomyces albus and Streptosporangium sibiricum."@cs . . . "185" . . . "Shared features and analysis of lincosamide and anthramycin antibiotic gene clusters"@en . "RIV/61388971:_____/04:00108133" . . "Kongres \u010Ceskoslovensk\u00E9 spole\u010Dnosti mikrobiologick\u00E9 /23./" . . "Kob\u011Brsk\u00E1, Mark\u00E9ta" . "Anal\u00FDza genov\u00E9ho clusteru anthramycinov\u00FDch a lincosamidov\u00FDch antibiotik"@cs . "2004-09-06+02:00"^^ . "6"^^ . . "lincosamide; anthramycin"@en . . "RIV/61388971:_____/04:00108133!RIV/2005/AV0/A53005/N" . "Sp\u00ED\u017Eek, Jaroslav" . "Z(AV0Z5020903)" . . "Lincomycin, produced by Streptomyces lincolnensis, is important, clinically used antibiotic. Its gene cluster consists of twenty-seven putative open reading frames with biosynthetic or regulatory functions and three resistance genes. Comparison of the chemical structure of the lincomycin and celesticetin indicates, that in the biosynthesis of celesticetin the whole propylproline branch is absent and proline is substrate of the penultimate step of biosynthesis, the condensation reaction. Second part of biosynthetic pathway including conversion of L-tyrosine to L-proline should be involved in the biosynthesis of functionally different anthramycin antibiotics. Thus it appears, that genetic information on lincomycin and anthramycin biosynthesis must also share common elements (genes), both biosynthetic and regulatory. The organization of transcription units was found. The analysis of the lincomycin biosynthetic gene transcripts in various cultivation stages revealed the genes with putat..." . "[73ACC5BC6950]" . "Jel\u00EDnkov\u00E1, Mark\u00E9ta" . "Lincomycin, produced by Streptomyces lincolnensis, is important, clinically used antibiotic. Its gene cluster consists of twenty-seven putative open reading frames with biosynthetic or regulatory functions and three resistance genes. Comparison of the chemical structure of the lincomycin and celesticetin indicates, that in the biosynthesis of celesticetin the whole propylproline branch is absent and proline is substrate of the penultimate step of biosynthesis, the condensation reaction. Second part of biosynthetic pathway including conversion of L-tyrosine to L-proline should be involved in the biosynthesis of functionally different anthramycin antibiotics. Thus it appears, that genetic information on lincomycin and anthramycin biosynthesis must also share common elements (genes), both biosynthetic and regulatory. The organization of transcription units was found. The analysis of the lincomycin biosynthetic gene transcripts in various cultivation stages revealed the genes with putat..."@en . "6"^^ . . "Shared features and analysis of lincosamide and anthramycin antibiotic gene clusters" . "Shared features and analysis of lincosamide and anthramycin antibiotic gene clusters" . . "\u010Cerm\u00E1k, Luk\u00E1\u0161" . "Neuveden" . .