"However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells."@en . . "\u0160ubr, Vladim\u00EDr" . . . "RIV/61388971:_____/04:00108060" . "Bou\u010Dek, Jan" . . "Mechanism of action of HPMA-based non-targeted polymeric prodrugs"@en . "3"^^ . "A\u010Dkoliv cytostatick\u00E9 polymern\u00ED konjug\u00E1ty na b\u00E1zi N-(2-hydroxypropyl)metakrylamidu jsou ji\u017E ve f\u00E1zi preklinick\u00FDch test\u016F, skute\u010Dn\u00FD mechanismus jejich \u00FA\u010Dinku nen\u00ED je\u0161t\u011B zcela objasn\u011Bn. Zd\u00E1 se \u017Ee \u0161t\u011Bpitelnost postrann\u00EDch peptidick\u00FDch \u0159et\u011Bzc\u016F nesouc\u00EDch cytostatikum nen\u00ED podm\u00EDnkou \u00FA\u010Dinnosti t\u011Bchto konjug\u00E1t\u016F a tyto \u0159et\u011Bzce jsou zodpov\u011Bdn\u00E9 sp\u00ED\u0161e za masivn\u00ED akumulaci t\u011Bchto l\u00E9\u010Div v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch."@cs . "Hovorka, Ond\u0159ej" . . "Z(AV0Z5020903)" . "Praha" . "Mechanism of action of HPMA-based non-targeted polymeric prodrugs" . "Praha" . "Mechanism of action of HPMA-based non-targeted polymeric prodrugs"@en . "Strohalm, Ji\u0159\u00ED" . . "hpma-dox; hpma-based"@en . . "7"^^ . "171" . "However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells." . . "Mechanismus p\u016Fsoben\u00ED polymern\u00EDch l\u00E9\u010Div na b\u00E1zi HPMA"@cs . . . "2004-10-13+02:00"^^ . . "International Conference on Tumor Microenvironment:Progression, Therapy and Prevention /3./" . "Neuveden" . . "Ulbrich, Karel" . . "[944A6AFD6F3E]" . . "1"^^ . "Mechanism of action of HPMA-based non-targeted polymeric prodrugs" . "Etrych, Tom\u00E1\u0161" . "Mechanismus p\u016Fsoben\u00ED polymern\u00EDch l\u00E9\u010Div na b\u00E1zi HPMA"@cs . . . "572737" . "RIV/61388971:_____/04:00108060!RIV/2005/AV0/A53005/N" . "\u0158\u00EDhov\u00E1, Blanka" . .