. "Intracellular destiny of HPMA based non-targeted polymeric produgs" . "RIV/61388971:_____/04:00107937!RIV/2005/GA0/A53005/N" . "Intracelul\u00E1rn\u00ED osud nesm\u011Brovan\u00FDch polymern\u00EDch l\u00E9\u010Div na b\u00E1zi HPMA"@cs . . "Intracelul\u00E1rn\u00ED osud nesm\u011Brovan\u00FDch polymern\u00EDch l\u00E9\u010Div na b\u00E1zi HPMA"@cs . . "Strohalm, Ji\u0159\u00ED" . "Annual Meeting and Exposition of the Controlled release Society /31./" . "Hovorka, Ond\u0159ej" . . . "Intracellular destiny and pharmacological effect of conjugates based on N-(2-hydroxypropyl)methacrylamide bearing doxorubicin is strongly influenced by their physico-chemical properties. Conjugates with doxorubicin attached via hydrolytically cleavable bond attack nuclear DNA and their effect is similar to free drug whereas conjugates with enzymatically cleavable spacer between drug and polymeric backbone desintegrates cellular membranes."@en . . "2"^^ . "Honolulu" . "568780" . . "Honolulu" . "hpma;dmem"@en . "2"^^ . "RIV/61388971:_____/04:00107937" . "Intracellular destiny and pharmacological effect of conjugates based on N-(2-hydroxypropyl)methacrylamide bearing doxorubicin is strongly influenced by their physico-chemical properties. Conjugates with doxorubicin attached via hydrolytically cleavable bond attack nuclear DNA and their effect is similar to free drug whereas conjugates with enzymatically cleavable spacer between drug and polymeric backbone desintegrates cellular membranes." . . "190;191" . "2004-06-12+02:00"^^ . . . . . "Etrych, Tom\u00E1\u0161" . "\u0158\u00EDhov\u00E1, Blanka" . "\u0160ubr, Vladim\u00EDr" . "7"^^ . "Intracellular destiny of HPMA based non-targeted polymeric produgs"@en . "[B23EC472305A]" . . . "Ulbrich, Karel" . "Neuveden" . "Zachar\u010Denko, M." . . "P(GA305/02/1425), P(GP305/04/P004)" . "Intracelul\u00E1rn\u00ED distribuce a \u00FA\u010Dinek polymern\u00EDch konjug\u00E1t\u016F na b\u00E1zi N-(2-hydroxypropyl)metakrylamidu nesouc\u00EDho cytostatikum doxorubicin je z\u00E1visl\u00FD na jejich struktu\u0159e. Zat\u00EDmco konjug\u00E1ty s hydrolyticky \u0161t\u011Bpitelnou vazbou mezi polymern\u00EDm nosi\u010Dem a l\u00E9\u010Divem napadaj\u00ED j\u00E1dro a jejich \u00FA\u010Dinek se bl\u00ED\u017E\u00ED \u00FA\u010Dink\u016Fm voln\u00E9ho l\u00E9\u010Diva, polymery nesouc\u00ED doxorubicin nav\u00E1zan\u00FD pomoc\u00ED enzymaticky \u0161t\u011Bpiteln\u00E9 spojky naru\u0161uj\u00ED sp\u00ED\u0161e membr\u00E1nov\u00FD syst\u00E9m bun\u011Bk a mechanismus jejich cytotoxick\u00E9ho \u00FA\u010Dinku je tak zcela jin\u00FD."@cs . . "Intracellular destiny of HPMA based non-targeted polymeric produgs"@en . "Intracellular destiny of HPMA based non-targeted polymeric produgs" . .