"NL - Nizozemsko" . "RIV/61388971:_____/02:00100411!RIV/2005/AV0/A53005/N" . "%22Zapojen\u00ED katecholaminov\u00FDch receptor\u016F (alfa-adrenergn\u00ED, D2-dopaminov\u00E9) bylo studov\u00E1no u stresovan\u00FDch experiment\u00E1ln\u00EDch zv\u00ED\u0159at. Stres vyvolal zm\u011Bn\u011Bn\u00E9 imunitn\u00ED odpov\u011Bdi spojen\u00E9 se zm\u011Bnami signalizace G-proteiny, po\u0161kozen\u00ED TH1/TH2 cytokinov\u00E9 s\u00EDt\u011B a funkce bun\u011Bk NK. Po aplikaci specifick\u00FDch antagonist\u016F p\u0159edch\u00E1zej\u00EDc\u00ED vyvol\u00E1n\u00ED stresu do\u0161lo k odstran\u011Bn\u00ED imunosuprese. D2\u2013typ dopaminergn\u00ED mechanismus representuje dominantn\u00ED komponentu v regulaci Galfas/Galfai (1,2)Galfaq/11 -proteinu p\u0159en\u00E1\u0161ej\u00EDc\u00EDho sign\u00E1l a funguj\u00EDc\u00EDho na obou -nervov\u00E9 a imunitn\u00ED \u00FArovni. S G-proteiny spojen\u00E9 receptory (GPCRs) mohou modulovat produkci cytokin\u016F a hr\u00E1t regula\u010Dn\u00ED \u00FAlohu v efektorov\u00FDch mechanismech imunity."@cs . "Posp\u00ED\u0161il, Miloslav" . "644405" . . "Starec, M." . "Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice"@en . . . . . "130" . . "7"^^ . . "0165-5728" . . "P\u00E1v, M." . "-" . . . "The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms." . "P(GA304/01/0850), P(GA310/98/0347), P(GV312/98/K034), Z(AV0Z5020903)" . . "3"^^ . "restraint stress; cytokine; nk cell"@en . "Vannucci, Luca" . . "The involvement of catecholamine receptors (alpha-adrenergic, D2-dopamine) was investigated in restraint animals. Stress influenced immune responses with concomitant changes of G-protein signal transduction. Impairment of TH1/TH2 cytokine network and natural killer (NK) cell function was observed. In vivo administration of specific antagonists prior to restraint stress reversed the immunosuppression. D2-type dopaminergic mechanism represents a dominant component in regulation of Galphas/Galphai(1,2)/Galphaq/11-protein signal transduction at level of both central nervous and immune systems. G-protein-coupled receptors (GPCRs) can modulate cytokine production and may play a regulatory role in immune effector mechanisms."@en . . . "Kuldov\u00E1, M." . . . "Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice" . "Fi\u0161erov\u00E1, Anna" . . "[640F66A6C277]" . "55;65" . "11"^^ . "Kov\u00E1\u0159\u016F, H." . . "RIV/61388971:_____/02:00100411" . "Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice" . "\u00DA\u010Dinek D2-dopaminov\u00FDch a alfa-adrenergn\u00EDch antagonist\u016F na stresem indukovan\u00E9 zm\u011Bny imunitn\u00ED odpovedi u my\u0161\u00ED"@cs . "Journal of Neuroimmunology" . "\u00DA\u010Dinek D2-dopaminov\u00FDch a alfa-adrenergn\u00EDch antagonist\u016F na stresem indukovan\u00E9 zm\u011Bny imunitn\u00ED odpovedi u my\u0161\u00ED"@cs . . . . "Effects of D2-dopamine and alfa-adrenoceptor antagonists in stress induced changes on immune reponsiveness of mice"@en .