"304433" . "57905" . "\u00DAstav organick\u00E9 chemie a biochemie AV \u010CR, v. v. i" . . . . "\u00DA\u0159ad pr\u016Fmyslov\u00E9ho vlastnictv\u00ED" . . "P\u00EDcha, Jan" . . "http://spisy.upv.cz/Patents/FullDocuments/304/304433.pdf" . "I" . . "Zp\u016Fsob p\u0159\u00EDpravy \u010Dist\u00E9 bezvod\u00E9 kyseliny (R)- nebo (S)-1,2-diaminopropan-N,N, N\u00B4,N\u00B4-tetraoctov\u00E9, kter\u00E1 je vyu\u017Eiteln\u00E1 v synt\u00E9ze kardioprotektivn\u00EDch l\u00E9\u010Div a chir\u00E1ln\u00EDch rozli\u0161ovac\u00EDch \u010Dinidel pro NMR spektroskopii. Vylep\u0161en\u00FD postup spo\u010D\u00EDv\u00E1 v tom, \u017Ee tato kyselina nen\u00ED p\u0159\u00EDmo syntetizov\u00E1na ve voln\u00E9 form\u011B, kter\u00E1 n\u00E1sledn\u011B vy\u017Eaduje komplikovan\u00E9 odsolov\u00E1n\u00ED a izolaci p\u0159es iontom\u011Bni\u010D, ale p\u0159iprav\u00ED se nejprve jej\u00ED tetrabenzylester, kter\u00FD lze pro jeho lipofiln\u00ED charakter snadno izolovat pomoc\u00ED chromatografie a/nebo extrakce do nepol\u00E1rn\u00EDho rozpou\u0161t\u011Bdla. Surov\u00FD tetrabenzylester se pot\u00E9 podrob\u00ED hydrogenol\u00FDze za p\u0159\u00EDtomnosti palladiov\u00E9ho katalyz\u00E1toru a takto vznikl\u00E1 surov\u00E1 tetrakyselina se v\u00FDhodn\u011B p\u0159e\u010Dist\u00ED krystalizac\u00ED ze sm\u011Bsi methanolu a vody, p\u0159i\u010Dem\u017E ji\u017E po jedn\u00E9 krystalizaci se z\u00EDsk\u00E1 c\u00EDlov\u00E1 tetrakyselina ve vysok\u00E9 \u010Distot\u011B a v bezvod\u00E9 form\u011B."@cs . . . . . . "2014-03-19+01:00"^^ . "Prague" . . . . . . . . "Zp\u016Fsob v\u00FDroby \u010Dist\u00FDch bezvod\u00FDch enantiomer\u016F kyseliny 1,2-diaminopropan-N,N,N\u00B4,N\u00B4-tetraoctov\u00E9"@cs . . . . "Zp\u016Fsob v\u00FDroby \u010Dist\u00FDch bezvod\u00FDch enantiomer\u016F kyseliny 1,2-diaminopropan-N,N,N\u00B4,N\u00B4-tetraoctov\u00E9"@cs . . "[6CC2F4B19774]" . . "Process for preparing pure anhydrous enantiomers of 1,2-diaminopropane-N,N,N\u00B4,N\u00B4-tetraacetic acid"@en . "In the present invention, there is disclosed a process for preparing pure anhydrous enantiomers of 1,2-diaminopropane-N,N,N\u00B4,N\u00B4-tetraacetic acid, which acid can be used in synthesis of cardio protective medicaments and chiral resolution agents for NMR spectroscopy. The improved preparation process is characterized in that the acid is not directly synthesized in free form, which subsequently requires complicated desalting and isolation through an ion-exchange resin. First, there is prepared the acid tetrabenzyl ester, which can be readily isolated because of its lipophilic nature by means of chromatography and/or extraction in a non-polar solvent. The raw tetrabenzyl ester is then subjected to hydrogenolysis in the presence of a palladium catalyst and so obtained raw tetra acid is preferably purified by crystallization from a mixture of methanol and water, whereby already one crystallization process provides the target tetra acid of high purity and in anhydrous form."@en . "Zp\u016Fsob v\u00FDroby \u010Dist\u00FDch bezvod\u00FDch enantiomer\u016F kyseliny 1,2-diaminopropan-N,N,N\u00B4,N\u00B4-tetraoctov\u00E9" . "chiral shift reagents; PDTA; 1,2-diaminopropane-N,N,N\u00B4,N\u00B4-tetraacetic acid; 1,2-diaminopropane"@en . . "RIV/61388963:_____/14:00435926" . "Zp\u016Fsob v\u00FDroby \u010Dist\u00FDch bezvod\u00FDch enantiomer\u016F kyseliny 1,2-diaminopropan-N,N,N\u00B4,N\u00B4-tetraoctov\u00E9" . "Process for preparing pure anhydrous enantiomers of 1,2-diaminopropane-N,N,N\u00B4,N\u00B4-tetraacetic acid"@en . "RIV/61388963:_____/14:00435926!RIV15-AV0-61388963" . "3"^^ . . . "Van\u011Bk, V\u00E1clav" . "Zp\u016Fsob p\u0159\u00EDpravy \u010Dist\u00E9 bezvod\u00E9 kyseliny (R)- nebo (S)-1,2-diaminopropan-N,N, N\u00B4,N\u00B4-tetraoctov\u00E9, kter\u00E1 je vyu\u017Eiteln\u00E1 v synt\u00E9ze kardioprotektivn\u00EDch l\u00E9\u010Div a chir\u00E1ln\u00EDch rozli\u0161ovac\u00EDch \u010Dinidel pro NMR spektroskopii. Vylep\u0161en\u00FD postup spo\u010D\u00EDv\u00E1 v tom, \u017Ee tato kyselina nen\u00ED p\u0159\u00EDmo syntetizov\u00E1na ve voln\u00E9 form\u011B, kter\u00E1 n\u00E1sledn\u011B vy\u017Eaduje komplikovan\u00E9 odsolov\u00E1n\u00ED a izolaci p\u0159es iontom\u011Bni\u010D, ale p\u0159iprav\u00ED se nejprve jej\u00ED tetrabenzylester, kter\u00FD lze pro jeho lipofiln\u00ED charakter snadno izolovat pomoc\u00ED chromatografie a/nebo extrakce do nepol\u00E1rn\u00EDho rozpou\u0161t\u011Bdla. Surov\u00FD tetrabenzylester se pot\u00E9 podrob\u00ED hydrogenol\u00FDze za p\u0159\u00EDtomnosti palladiov\u00E9ho katalyz\u00E1toru a takto vznikl\u00E1 surov\u00E1 tetrakyselina se v\u00FDhodn\u011B p\u0159e\u010Dist\u00ED krystalizac\u00ED ze sm\u011Bsi methanolu a vody, p\u0159i\u010Dem\u017E ji\u017E po jedn\u00E9 krystalizaci se z\u00EDsk\u00E1 c\u00EDlov\u00E1 tetrakyselina ve vysok\u00E9 \u010Distot\u011B a v bezvod\u00E9 form\u011B." . . "Bud\u011B\u0161\u00EDnsk\u00FD, Milo\u0161" . "3"^^ .