"7103" . "I, P(GA13-26526S)" . "oligonucleotides; phosphonates; RNase H; RNase L"@en . "Chemie fosfon\u00E1tov\u00FDch analog\u016F nukleotid\u016F a oligonukleotid\u016F - stru\u010Dn\u00E1 reminiscence a sou\u010Dasnost"@cs . "Chemie fosfon\u00E1tov\u00FDch analog\u016F nukleotid\u016F a oligonukleotid\u016F - stru\u010Dn\u00E1 reminiscence a sou\u010Dasnost"@cs . . . "Our investigation in the chemistry of nucleoside phosphonates has provided an impressive number of novel structurally diverse compounds. Among them, several potent inhibitors of enzymes of nucleosides and nucleotide salvage pathways were found. The findings obtained in synthesis of nucleoside phosphonates are unique. The nucleoside phosphonates provided several types of monomers for the synthesis of modified oligonucleotides. The first non-silyl protecting group was developed and used in the solid-phase synthesis of modified oligoribonucleotides in the reverse direction. The superior nuclease stability of phosphonate internucleotide linkages, their ability to enhance hybridization together with the ability to elicit RNase H activity may classify these compounds as useful in biochemistry and biology."@en . . "12"^^ . . . "Rosenberg, Ivan" . . . "RIV/61388963:_____/14:00429742" . . "[578FA707C493]" . . "CZ - \u010Cesk\u00E1 republika" . "Chemie fosfon\u00E1tov\u00FDch analog\u016F nukleotid\u016F a oligonukleotid\u016F - stru\u010Dn\u00E1 reminiscence a sou\u010Dasnost" . "RIV/61388963:_____/14:00429742!RIV15-GA0-61388963" . "4" . "0009-2770" . . "1"^^ . "Chemistry of Phosphonate Analogs of Nucleotides and Oligonucleotides - Brief Reminiscence and the Present"@en . . "1"^^ . . "108" . . "Chemick\u00E9 listy" . . "Chemie fosfon\u00E1tov\u00FDch analog\u016F nukleotid\u016F a oligonukleotid\u016F - stru\u010Dn\u00E1 reminiscence a sou\u010Dasnost" . "000336833500014" . . "Na\u0161e zkoum\u00E1n\u00ED v oblasti chemie nukleosidfosfonov\u00FDch kyselin poskytlo nep\u0159ehl\u00E9dnuteln\u00E9 mno\u017Estv\u00ED nov\u00FDch, strukturn\u011B rozd\u00EDln\u00FDch l\u00E1tek. Mezi nimi bylo nalezeno n\u011Bkolik siln\u00FDch inhibitor\u016F enzym\u016F metabolizuj\u00EDc\u00EDch p\u0159irozen\u00E9 nukleosidy a nukleotidy (salvage pathways enzymes). Unik\u00E1tn\u00ED poznatky z\u00EDskan\u00E9 p\u0159i synt\u00E9ze nukleosidfosfonov\u00FDch kyselin jsou zhodnocov\u00E1ny p\u0159i p\u0159\u00EDprav\u011B monomer\u016F pro p\u0159\u00EDpravu modifikovan\u00FDch oligonukleotid\u016F. Byla vyvinuta nov\u00E1 nesilylov\u00E1 chr\u00E1n\u00EDc\u00ED skupina monomer\u016F a pou\u017Eita p\u0159i synt\u00E9ze modifikovan\u00FDch oligoribonukleotid\u016F na pevn\u00E9 f\u00E1zi v obr\u00E1cen\u00E9m sm\u011Bru. Vynikaj\u00EDc\u00ED nukleasov\u00E1 stabilita fosfon\u00E1tov\u00FDch internukleotidov\u00FDch vazeb, jejich schopnost zvy\u0161ovat hybridizaci a stimulaci ribonukleasy H klasifikuje tyto l\u00E1tky jako slibn\u00E9 n\u00E1stroje pro biochemii a biologii." . "Chemistry of Phosphonate Analogs of Nucleotides and Oligonucleotides - Brief Reminiscence and the Present"@en . . "Na\u0161e zkoum\u00E1n\u00ED v oblasti chemie nukleosidfosfonov\u00FDch kyselin poskytlo nep\u0159ehl\u00E9dnuteln\u00E9 mno\u017Estv\u00ED nov\u00FDch, strukturn\u011B rozd\u00EDln\u00FDch l\u00E1tek. Mezi nimi bylo nalezeno n\u011Bkolik siln\u00FDch inhibitor\u016F enzym\u016F metabolizuj\u00EDc\u00EDch p\u0159irozen\u00E9 nukleosidy a nukleotidy (salvage pathways enzymes). Unik\u00E1tn\u00ED poznatky z\u00EDskan\u00E9 p\u0159i synt\u00E9ze nukleosidfosfonov\u00FDch kyselin jsou zhodnocov\u00E1ny p\u0159i p\u0159\u00EDprav\u011B monomer\u016F pro p\u0159\u00EDpravu modifikovan\u00FDch oligonukleotid\u016F. Byla vyvinuta nov\u00E1 nesilylov\u00E1 chr\u00E1n\u00EDc\u00ED skupina monomer\u016F a pou\u017Eita p\u0159i synt\u00E9ze modifikovan\u00FDch oligoribonukleotid\u016F na pevn\u00E9 f\u00E1zi v obr\u00E1cen\u00E9m sm\u011Bru. Vynikaj\u00EDc\u00ED nukleasov\u00E1 stabilita fosfon\u00E1tov\u00FDch internukleotidov\u00FDch vazeb, jejich schopnost zvy\u0161ovat hybridizaci a stimulaci ribonukleasy H klasifikuje tyto l\u00E1tky jako slibn\u00E9 n\u00E1stroje pro biochemii a biologii."@cs . .