. "Bud\u011B\u0161\u00EDnsk\u00FD, Milo\u0161" . "7"^^ . "Demianova, Zuzana" . "BHMT-2 methyltransferase catalyzes the transfer of a methyl group from S-methylmethionine to L-homocysteine, yielding two molecules of L-methionine. In this study, we have prepared the first series of BHMT-2 inhibitors to be described, and we have tested them with human recombinant BHMT-2 that has been stabilized by copurification with human recombinant BHMT. Among the compounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid was the most potent (Ki app about 77 nM) and selective inhibitor of BHMT-2. This compound may be useful in future in vivo studies to probe the physiological significance of BHMT-2 in sulfur amino acid metabolism."@en . . "10.1021/jm300571h" . . . "Demianova, Zuzana" . "6"^^ . "132131" . "BHMT-2 methyltransferase catalyzes the transfer of a methyl group from S-methylmethionine to L-homocysteine, yielding two molecules of L-methionine. In this study, we have prepared the first series of BHMT-2 inhibitors to be described, and we have tested them with human recombinant BHMT-2 that has been stabilized by copurification with human recombinant BHMT. Among the compounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid was the most potent (Ki app about 77 nM) and selective inhibitor of BHMT-2. This compound may be useful in future in vivo studies to probe the physiological significance of BHMT-2 in sulfur amino acid metabolism." . "Ml\u00E1dkov\u00E1, Jana" . "Van\u011Bk, V\u00E1clav" . . "Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2" . . "Elbert, Tom\u00E1\u0161" . "RIV/61388963:_____/12:00379825" . "0022-2623" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "RIV/61388963:_____/12:00379825!RIV13-AV0-61388963" . . . "Jir\u00E1\u010Dek, Ji\u0159\u00ED" . "10"^^ . "betaine; homocysteine; methionine; BHMT; inhibitor"@en . . . . . . . "Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2"@en . "000307264100015" . . "I, P(GA203/09/1919), P(GAP207/10/1277)" . . "Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2"@en . "Journal of Medicinal Chemistry" . . . . "Garrow, T. A." . . "[6C409884FF3B]" . "Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2" . . "15" . . "55" .