"DE - Spolkov\u00E1 republika N\u011Bmecko" . "0039-7881" . "A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides"@en . . "I, P(IAA400550902), P(LC512), Z(AV0Z40550506)" . "120229" . "Kubelka, Tom\u00E1\u0161" . . . . . "44" . "RIV/61388963:_____/12:00377772!RIV13-AV0-61388963" . "RIV/61388963:_____/12:00377772" . "Slav\u011Bt\u00EDnsk\u00E1, Lenka" . . . . . . "3"^^ . "A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides" . "10.1055/s-0031-1289694" . "A new modular synthesis of diverse 2,4-disubstituted pyrimidin-5-yl C-2'-deoxyribonucleosides by sequential regioselective reactions of 2,6-dichloropyrimidin-5-yl C-nucleoside was developed. The intermediate was prepared by the Heck coupling of 2,6-dichloro-5-iodopyrimidine with glycal followed by desilylation and reduction. Its mild nucleophilic substitutions or cross-coupling reactions proceeded regioselectively at position 4, while at elevated temperatures or with excess reagent, a double substitution occurred. The 2-chloro-4-substituted intermediates underwent another substitution or coupling to afford a two-dimensional library of diverse 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleotides." . "6" . "A new modular synthesis of diverse 2,4-disubstituted pyrimidin-5-yl C-2'-deoxyribonucleosides by sequential regioselective reactions of 2,6-dichloropyrimidin-5-yl C-nucleoside was developed. The intermediate was prepared by the Heck coupling of 2,6-dichloro-5-iodopyrimidine with glycal followed by desilylation and reduction. Its mild nucleophilic substitutions or cross-coupling reactions proceeded regioselectively at position 4, while at elevated temperatures or with excess reagent, a double substitution occurred. The 2-chloro-4-substituted intermediates underwent another substitution or coupling to afford a two-dimensional library of diverse 2,4-disubstituted pyrimidin-5-yl C-2-deoxyribonucleotides."@en . "Hocek, Michal" . . . "nucleosides; pyrimidines; cross-coupling; Heck reaction"@en . "3"^^ . "A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides"@en . . . "Synthesis" . "13"^^ . . . . "[89FC1539A8ED]" . . "000301344200017" . . . "A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides" . . . .