. "We recently introduced a furan-oxidation-based methodology for crosslinking of nucleic acids. Given the destabilization of duplexes observed upon introduction of the initially designed furan-modified building block into DNA duplexes, we explore here the potential benefits of two new building blocks featuring an extended aromatic system and a restored cyclic backbone. Thorough experimental analysis of crosslinking reactions in a series of contexts, combined with theoretical calculations, permit structural characterization of the formed species and allow assessment of the origin of the enhanced cross-link selectivity. Our experiments clearly show that the modular nature of the furan-modified building blocks used in the current cross-linking strategy allow for fine tuning of both yield and selectivity of the interstrand crosslinking reaction."@en . "Speybroeck, V. V." . . "Stevens, K." . "bioorganic chemistry; DNA; molecular modeling; nucleosides; oxidation"@en . "Catak, S." . . . . "200655" . "Sch\u00FCrch, S." . "P(IAA400550902), P(LC512), Z(AV0Z40550506)" . "We recently introduced a furan-oxidation-based methodology for crosslinking of nucleic acids. Given the destabilization of duplexes observed upon introduction of the initially designed furan-modified building block into DNA duplexes, we explore here the potential benefits of two new building blocks featuring an extended aromatic system and a restored cyclic backbone. Thorough experimental analysis of crosslinking reactions in a series of contexts, combined with theoretical calculations, permit structural characterization of the formed species and allow assessment of the origin of the enhanced cross-link selectivity. Our experiments clearly show that the modular nature of the furan-modified building blocks used in the current cross-linking strategy allow for fine tuning of both yield and selectivity of the interstrand crosslinking reaction." . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "RIV/61388963:_____/11:00361001" . . "Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone"@en . "1"^^ . "17" . . . . "Hocek, Michal" . . "000292206600011" . "Claeys, D. D." . . "Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone" . . "Chemistry - A European Journal" . "10.1002/chem.201100067" . . . "Figaroli, S." . "Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone" . "RIV/61388963:_____/11:00361001!RIV12-AV0-61388963" . "14"^^ . "0947-6539" . . . "Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone"@en . "Madder, A." . . . "Tromp, J. M." . "25" . "9"^^ . "[3EA671E05202]" . . . .