"SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors" . . "RIV/61388963:_____/11:00360813!RIV12-AV0-61388963" . . . "6"^^ . "RIV/61388963:_____/11:00360813" . . "SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors"@en . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "10.1016/j.bmcl.2011.05.070" . "9"^^ . . "[E88B5A9CF7A5]" . . "Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series." . "H\u0159ebabeck\u00FD, Hubert" . "0960-894X" . . . . "Nencka, Radim" . "Mertl\u00EDkov\u00E1-Kaiserov\u00E1, Helena" . . "228144" . "P(1M0508), P(GAP303/11/1297), Z(AV0Z40550506)" . . . . "Bioorganic and Medicinal Chemistry Letters" . . . . . "14" . "Dra\u010D\u00EDnsk\u00FD, Martin" . "SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors" . . "21" . . "De Palma, A. M." . "Leyssen, P." . "SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors"@en . . "Dejmek, Milan" . "coxsackievirus; norbornane; picornaviruses"@en . "Coxsackievirus and related enteroviruses are important human pathogens that cause various diseases with clinical manifestations ranging from trivial flu-like syndromes to dangerous or even fatal diseases such as myocarditis, meningitis and encephalitis. Here, we report on our continuous SAR study focused on 9-(bicyclo[2.2.1]hept-2-yl)-9H-purines as anti-enteroviral inhibitors. The purine moiety was modified at positions 2, 6 and 8. Several analogues inhibited coxsackievirus B3 as well as other enteroviruses at low-micromolar concentrations. The 6-chloropurine derivative was confirmed as the most active compound in this series."@en . . . "5"^^ . "Neyts, J." . "\u0160\u00E1la, Michal" . . "000292186400033" .