. "Two convergent approaches toward novel carbocyclic C-nucleosides"@en . . . "H\u0159ebabeck\u00FD, Hubert" . "Dra\u010D\u00EDnsk\u00FD, Martin" . "Two convergent approaches toward novel carbocyclic C-nucleosides" . "0039-7881" . "293853" . . "RIV/61388963:_____/10:00351443" . "Two convergent approaches toward novel carbocyclic C-nucleosides" . . "Two convergent methodologies for construction of novel carbocyclic C-nucleosides allowing the syntheses of derivatives with uracil heterobase substituted at the position C-5 as well as C-6 were developed. The crucial step of the first methodology was the reaction of (6-chloro-2,4-dimethoxypyrimidin-5-yl)lithium, the nucleobase precursor, with suitable ketones, the carbocyclic pseudosugar precursors. The second approach was based on the copper-catalyzed cross-coupling between magnesiated pyrimidine and appropriate allyl chlorides. These methodologies were applied for the synthesis of novel carbocyclic C-nucleosides bearing cyclohexene or cyclohexane as a pseudosugar." . "Hol\u00FD, Anton\u00EDn" . . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Two convergent approaches toward novel carbocyclic C-nucleosides"@en . . . . . "RIV/61388963:_____/10:00351443!RIV11-MSM-61388963" . . "-" . . "[35B408D49522]" . . . "Nencka, Radim" . . "12"^^ . . "000284535900028" . . . . "Synthesis" . "6"^^ . "P(1M0508), Z(AV0Z40550506)" . "23" . . . "\u0160\u00E1la, Michal" . "6"^^ . "Two convergent methodologies for construction of novel carbocyclic C-nucleosides allowing the syntheses of derivatives with uracil heterobase substituted at the position C-5 as well as C-6 were developed. The crucial step of the first methodology was the reaction of (6-chloro-2,4-dimethoxypyrimidin-5-yl)lithium, the nucleobase precursor, with suitable ketones, the carbocyclic pseudosugar precursors. The second approach was based on the copper-catalyzed cross-coupling between magnesiated pyrimidine and appropriate allyl chlorides. These methodologies were applied for the synthesis of novel carbocyclic C-nucleosides bearing cyclohexene or cyclohexane as a pseudosugar."@en . "Dejmek, Milan" . . . "carbocyclic C-nucleosides; convergent approach; uracil; pyrimidines"@en .