"Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11\u201345 nM. These most potent compounds might be bi-substrate analogues." . "290435" . "Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase"@en . "Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase"@en . . . "Structurally diverse, sugar-modified, thymine-containing nucleoside phosphonic acids were evaluated for their ability to inhibit thymidine phosphorylase purified from spontaneous T-cell lymphomas of an inbred Sprague-Dawley rat strain. From a large set of tested compounds, among them a number of pyrrolidine-based derivatives, 10 nucleotide analogues with IC50 values below 1 .mu.M were selected. Out of them, four compounds strongly inhibited the enzyme with IC50 values in a range of 11\u201345 nM. These most potent compounds might be bi-substrate analogues."@en . "P(1QS400550501), P(2B06065), P(GA202/09/0193), P(GA203/09/0820), P(KAN200520801), P(LC06061), P(LC06077), P(NR9138), Z(AV0Z40550506)" . . "Pohl, Radek" . . . "Bioorganic and Medicinal Chemistry Letters" . "Tome\u010Dkov\u00E1, Ivana" . "phosphonate nucleotides; pyrrolidine; thymidine phosphorylase"@en . "Bud\u011B\u0161\u00EDnsk\u00FD, Milo\u0161" . . "4"^^ . "Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase" . "RIV/61388963:_____/10:00345860!RIV11-GA0-61388963" . "Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase" . . . . . . "Panova, Natalya" . . . . "Votruba, Ivan" . . "Rejman, Dominik" . . "Kr\u00E1l\u00EDkov\u00E1, \u0160\u00E1rka" . . . . . "Van\u011Bk, V\u00E1clav" . . . . . . . "0960-894X" . . "Rinnov\u00E1, Mark\u00E9ta" . "P\u00E1v, Ond\u0159ej" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "Rosenberg, Ivan" . "RIV/61388963:_____/10:00345860" . "000273783800014" . . "15"^^ . . . "To\u010D\u00EDk, Zden\u011Bk" . . . "15"^^ . . . "Petrov\u00E1, Magdalena" . . "Ko\u010Dalka, Petr" . "Liboska, Radek" . "Panova, Natalya" . . "20" . "3" . . "[98036BCFC18F]" .