. . "Z(AV0Z40550506)" . "Satchell, K. J. F." . "Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites"@en . "RIV/61388963:_____/09:00336360!RIV10-AV0-61388963" . "autoprocessing; activator InsP6 inositol hexakisphosphate; CPD cysteine protease domain; MARTX(Vc)"@en . . "[0E75138F4310]" . "12"^^ . . "0021-9258" . "Journal of Biological Chemistry" . "6"^^ . . "Shuvalova, L. A." . "39" . "Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites" . . . "Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites"@en . . . "284" . . "1"^^ . "The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protease domain (CPD). The CPD is activated upon binding inositol hexakisphosphate (InsP6). In this study, we demonstrated that InsP6 is not simply an allosteric cofactor, but rather binding of InsP6 stabilized the CPD structure, facilitating formation of the enzyme-substrate complex." . . "The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protease domain (CPD). The CPD is activated upon binding inositol hexakisphosphate (InsP6). In this study, we demonstrated that InsP6 is not simply an allosteric cofactor, but rather binding of InsP6 stabilized the CPD structure, facilitating formation of the enzyme-substrate complex."@en . "344119" . . "RIV/61388963:_____/09:00336360" . . "Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites" . "Voburka, Zden\u011Bk" . "000269969600037" . . "Anderson, W. F." . "Proch\u00E1zkov\u00E1, K." . "Minasov, G." . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . .