"52" . "Hockov\u00E1, Dana" . "Plasmodium falciparum (Pf) relies on the purine salvage enzyme, hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), for the synthesis of the mononucleotides. Acyclic nucleoside phosphonates (ANPs) are structural analogs of the mononucleotide product of the reaction and contain a purine base linked by different combinations of atoms to a phosphonate group. Ki values for 19 ANPs were determined for PfHGXPRT and human HGPRT. IC50 values for Pf grown in cell culture and the structures of human HGPRT in complex with three ANPs have been determined. These results provide a basis for the design of more potent and selective inhibitors as anti-malarial drugs with novel mode of action."@en . "Skinner-Adams, T. S." . . "000268139900034" . . . "Hol\u00FD, Anton\u00EDn" . . . "RIV/61388963:_____/09:00329059!RIV10-MSM-61388963" . . "P(1M0508), P(1QS400550501), Z(AV0Z40550506)" . "[0A920C90D4EA]" . "Naesens, L." . . . . . "de Jersey, J." . . "Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Guddat, L. W." . . "Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics"@en . . . "7"^^ . "14" . . . . . "319546" . "Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics"@en . "0022-2623" . "Journal of Medicinal Chemistry" . "RIV/61388963:_____/09:00329059" . "Keough, D. T." . . "Plasmodium falciparum (Pf) relies on the purine salvage enzyme, hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), for the synthesis of the mononucleotides. Acyclic nucleoside phosphonates (ANPs) are structural analogs of the mononucleotide product of the reaction and contain a purine base linked by different combinations of atoms to a phosphonate group. Ki values for 19 ANPs were determined for PfHGXPRT and human HGPRT. IC50 values for Pf grown in cell culture and the structures of human HGPRT in complex with three ANPs have been determined. These results provide a basis for the design of more potent and selective inhibitors as anti-malarial drugs with novel mode of action." . "2"^^ . . "Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: A new class of antimalarial therapeutics" . "9"^^ . "acyclic nucleoside phosphonates; phosphoribosyltransferase; enzyme inhibitors; Plasmodium falciparum"@en .