. "Gammon, D. B." . "82" . "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" . . "378289" . "P(1M0508), P(1QS400550501), Z(AV0Z40550506)" . "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs"@en . "[D18C23F6896D]" . "Kre\u010Dmerov\u00E1, Marcela" . "S-HPMPDAP-resistant vaccinia virus mutants were generated. All of the mutant viruses still exhibited a variable degree of reduced virulence in a mouse intranasal challenge model. Infections caused by these drug-resistant viruses in mice were still treatable with higher concentrations of the ANPs."@en . . "Mechanismus resistence viru vakcinie v\u016F\u010Di protivirov\u00FDm l\u00E1tk\u00E1m: Identifikace zbytk\u016F ve virov\u00E9 DNA polymerase ud\u011Bluj\u00EDc\u00EDch rozd\u00EDlnou resistenci k l\u00E9\u010Div\u016Fm proti poxvir\u016Fm"@cs . "Evans, D. H." . "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs" . "Byly vytvo\u0159eny mutanty viru vakcinie resistentn\u00ED k (S)-HPMPDAP. V\u0161echny z t\u011Bchto virov\u00FDch mutant\u016F je\u0161t\u011B vykazovaly r\u016Fzn\u00FD stupe\u0148 sn\u00ED\u017Een\u00E9 virulence u my\u0161\u00EDho modelu p\u0159i intranas\u00E1ln\u00ED aplikaci. Infekce zp\u016Fsoben\u00E9 t\u011Bmito k l\u00E9\u010Div\u016Fm resistentn\u00EDmi viry byly u my\u0161\u00ED je\u0161t\u011B st\u00E1le l\u00E9\u010Diteln\u00E9 vy\u0161\u0161\u00EDmi d\u00E1vkami acyklick\u00FDch nukleosidfosfon\u00E1t\u016F."@cs . "De Clercq, E." . "0022-538X" . . . "9"^^ . . . . "Fiten, P." . . "24" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Mechanism of antiviral drug resistance of vaccinia virus: Identification of residues in the viral DNA polymerase conferring differential resistance to anti-poxvirus drugs"@en . "15"^^ . . . . . "Hol\u00FD, Anton\u00EDn" . "Mechanismus resistence viru vakcinie v\u016F\u010Di protivirov\u00FDm l\u00E1tk\u00E1m: Identifikace zbytk\u016F ve virov\u00E9 DNA polymerase ud\u011Bluj\u00EDc\u00EDch rozd\u00EDlnou resistenci k l\u00E9\u010Div\u016Fm proti poxvir\u016Fm"@cs . "2"^^ . "Opdenakker, G." . "Snoeck, R." . . . "000261164000051" . "RIV/61388963:_____/08:00315205!RIV09-AV0-61388963" . . "Andrei, G." . "RIV/61388963:_____/08:00315205" . "Journal of Virology" . . . "vaccinia; drug resistence; poxivirus; acyclic nucleoside phosphonates; (S)-HPMPDAP"@en . . . . "S-HPMPDAP-resistant vaccinia virus mutants were generated. All of the mutant viruses still exhibited a variable degree of reduced virulence in a mouse intranasal challenge model. Infections caused by these drug-resistant viruses in mice were still treatable with higher concentrations of the ANPs." .