"365197" . . "Retroviral capsid protein (CA) mediates interactions driving the assembly of both immature and mature virions. To investigate the role of Pro1 and its interacting Asp in M-PMV core assembly and infectivity, P1A, P1Y, D50A, T54A and D57A mutations were introduced into CA. The P1A and D57A mutations blocked Gag processing and the virus exhibited aberrant cores and were noninfectious. These data indicate that the Asp50-Asp57 region plays an important role in stabilization of the beta-hairpin."@en . . . . . "Hadravov\u00E1, Romana" . . . "Vliv bodov\u00FDch mutac\u00ED N-koncov\u00E9 dom\u00E9ny kapsidov\u00E9ho proteinu z Mason-Pfizerova opi\u010D\u00EDho viru na skl\u00E1d\u00E1n\u00ED virov\u00E9ho core a infektivitu"@cs . . . "000259800500020" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "[47E07EFC2B9E]" . "0042-6822" . . "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity"@en . . . "Virology" . "Ruml, Tom\u00E1\u0161" . . "7"^^ . "380" . . . . . "8"^^ . . "Retrovirov\u00FD kapsidov\u00FD protein (CA) zprost\u0159edkov\u00E1v\u00E1 interakce vedouc\u00ED ke skl\u00E1d\u00E1n\u00ED jak nezral\u00E9, tak zral\u00E9 virov\u00E9 \u010D\u00E1stice. Pro studium role Pro1 a s n\u00EDm interaguj\u00EDc\u00EDch Asp zbytk\u016F v CA M-PMV p\u0159i skl\u00E1d\u00E1n\u00ED zral\u00E9ho core, byly do sekvence CA zavedeny bodov\u00E9 mutace P1A, P1Y, D50A, T54A a D57A. Mutace P1A a D57A blokovaly \u0161t\u011Bpen\u00ED polyproteinu Gag, virov\u00E9 \u010D\u00E1stice m\u011Bly po\u0161kozen\u00E1 core a byly neinfek\u010Dn\u00ED. Tato data nazna\u010Duj\u00ED, \u017Ee oblast CA, zahrnuj\u00EDc\u00ED Asp50-Asp57 hraje d\u016Fle\u017Eitou roli ve stabilizaci beta-smy\u010Dky ."@cs . "Pichov\u00E1, Iva" . "\u0160tokrov\u00E1, Jitka" . "caspid protein; assembly; M-PMV"@en . "P(1M0508), P(1M0520), P(GESCO/06/E001), P(KAN200200651), P(KAN208240651), Z(AV0Z40550506), Z(MSM6046137305)" . "1" . "K\u0159\u00ED\u017Eov\u00E1, Ivana" . "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity"@en . "7"^^ . . . . . . "RIV/61388963:_____/08:00313431!RIV09-AV0-61388963" . . "Vliv bodov\u00FDch mutac\u00ED N-koncov\u00E9 dom\u00E9ny kapsidov\u00E9ho proteinu z Mason-Pfizerova opi\u010D\u00EDho viru na skl\u00E1d\u00E1n\u00ED virov\u00E9ho core a infektivitu"@cs . "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" . "RIV/61388963:_____/08:00313431" . "The effect of point mutations within the N-terminal domain of Mason-Pfizer monkey virus capsid protein on virus core assembly and infectivity" . "Retroviral capsid protein (CA) mediates interactions driving the assembly of both immature and mature virions. To investigate the role of Pro1 and its interacting Asp in M-PMV core assembly and infectivity, P1A, P1Y, D50A, T54A and D57A mutations were introduced into CA. The P1A and D57A mutations blocked Gag processing and the virus exhibited aberrant cores and were noninfectious. These data indicate that the Asp50-Asp57 region plays an important role in stabilization of the beta-hairpin." . . . "Wildov\u00E1, Marcela" . . "Rumlov\u00E1, Michaela" . "Hunter, E." .