"US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "RIV/61388963:_____/08:00313426" . "6"^^ . "Knejzl\u00EDk, Z." . . "Srb, P." . "3"^^ . "D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein" . . . "Veverka, V." . . "[78672554BA26]" . . "Hunter, E." . "D-type retrovirus M-PMV assembles its immature particles within the cytoplasm of the infected cell. A mutation R55F redirects assembly from a cytoplasmic site to the plasma membrane. In this work it is shown that this switch is caused by inability of R55F to bind cellular protein Tctex-1, a part of dynein, mediating the targeting wt M-PMV to the site of assembly. Comparison of NMR structures of MA wt and R55F revealed the structural change, preventing Tctex-1 binding to R55F." . "D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein"@en . "Lang, J." . "11"^^ . . "Vlach, J." . . "Hrabal, J." . "Lipov, J." . . . "D-type retrovirus M-PMV assembles its immature particles within the cytoplasm of the infected cell. A mutation R55F redirects assembly from a cytoplasmic site to the plasma membrane. In this work it is shown that this switch is caused by inability of R55F to bind cellular protein Tctex-1, a part of dynein, mediating the targeting wt M-PMV to the site of assembly. Comparison of NMR structures of MA wt and R55F revealed the structural change, preventing Tctex-1 binding to R55F."@en . "RIV/61388963:_____/08:00313426!RIV09-AV0-61388963" . . "000258211600053" . . "Pichov\u00E1, Iva" . "Rumlov\u00E1, Michaela" . . . "Ruml, Tom\u00E1\u0161" . . "364398" . "0027-8424" . . . . . "105" . "P(GA203/03/0490), P(GESCO/06/E001), P(GP203/02/P098), P(KAN200100801), P(ME 904), Z(AV0Z40550506), Z(MSM0021620835), Z(MSM6046137305)" . "D-typ retrovir\u016F M-PMV skl\u00E1d\u00E1 sv\u00E9 nezral\u00E9 \u010D\u00E1stice v cytoplasm\u011B infikovan\u00E9 bu\u0148ky. Mutace R55F v matrixov\u00E9m proteinu (MA) zm\u011Bn\u00ED m\u00EDsto skl\u00E1d\u00E1n\u00ED z cytoplasmy na cytoplasmatickou membr\u00E1nu. V t\u00E9to pr\u00E1ci je uk\u00E1z\u00E1no, \u017Ee tato zm\u011Bna je vyvolan\u00E1 neschopnost\u00ED R55F mutantu v\u00E1zat bun\u011B\u010Dn\u00FD protein Tctex-1, kter\u00FD jako sou\u010D\u00E1st dyneinov\u00E9ho motoru, zprost\u0159edkov\u00E1v\u00E1 c\u00EDlen\u00ED wt M-PMV polyprotein\u016F na m\u00EDsto skl\u00E1d\u00E1n\u00ED. Porovn\u00E1n\u00EDm NMR struktur MA wt a R55F byla odhalena strukturn\u00ED zm\u011Bna, zabra\u0148uj\u00EDc\u00ED vazb\u011B Tctex-1 k R55F MA."@cs . . "Zm\u011Bna morfologie retroviru typu D je z\u00E1visl\u00E1 na p\u0159\u00EDstupnosti strukturn\u00EDho motivu pro vazbu Tctex-1 \u0159et\u011Bzce dyneinov\u00E9ho motoru"@cs . . . "Zm\u011Bna morfologie retroviru typu D je z\u00E1visl\u00E1 na p\u0159\u00EDstupnosti strukturn\u00EDho motivu pro vazbu Tctex-1 \u0159et\u011Bzce dyneinov\u00E9ho motoru"@cs . "D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein"@en . . . "Proceedings of the National Academy of Sciences of the United States of America" . "structure of matrix protein; transport; retrovirus"@en . . "D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein" . . "30" .