. . . "Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir" . . . "Tato pr\u00E1ce charakterizuje vliv mutac\u00ED I47A a I54V v HIV-1 protease na sn\u00ED\u017Eenou citlivost k inbitoru lopinaviru a vzu\u017E\u00EDv\u00E1 enzymatick\u00E9 a struktur\u00E1ln\u00ED metody a take metody molekulov\u00E9 dynamiky. V\u00FDsledky pr\u00E1ce n\u00E1m mohou pomoci porozum\u011Bt l\u00E9pe v\u00FDvoji resistence k proteasov\u00FDm inhibitor\u016Fm."@cs . . . "[CEF27EE9EF5F]" . . "Kagan, R. M." . "Enzymatick\u00E1 a struktur\u00E1ln\u00ED charakterizace mutace I47A pod\u00EDlej\u00EDc\u00ED se na sn\u00ED\u017E\u0161n\u00E9 citlivosti k HIV proteasov\u00E9mu inhibitoru lopinaviru"@cs . . "Grantz \u0160a\u0161kov\u00E1, Kl\u00E1ra" . "RIV/61388963:_____/08:00312673" . "This paper characterizes the influence of I47A and I54V mutations on the susceptibility to protease inhibitor lopinavir using enzymatic, structural and molecular dynamics analysis. The results may help us understanding development of the resistance to HIV protease inhibitors." . "Lep\u0161\u00EDk, Martin" . . "17" . "P(1M0508), P(NR8571), R, Z(AV0Z40550506), Z(AV0Z50520514)" . "HIV protease inhibitors; antiviral resistance development; X-ray structure; molecular recognition; enzyme kinetics"@en . "Brynda, Ji\u0159\u00ED" . . "0961-8368" . "9" . "12"^^ . . . . . . . "366358" . . "9"^^ . "Protein Science" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "This paper characterizes the influence of I47A and I54V mutations on the susceptibility to protease inhibitor lopinavir using enzymatic, structural and molecular dynamics analysis. The results may help us understanding development of the resistance to HIV protease inhibitors."@en . "Konvalinka, Jan" . "Prejdov\u00E1, Jana" . . "Enzymatick\u00E1 a struktur\u00E1ln\u00ED charakterizace mutace I47A pod\u00EDlej\u00EDc\u00ED se na sn\u00ED\u017E\u0161n\u00E9 citlivosti k HIV proteasov\u00E9mu inhibitoru lopinaviru"@cs . . . "\u0158ez\u00E1\u010Dov\u00E1, Pavl\u00EDna" . "6"^^ . "Machala, L." . . "Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir" . . "RIV/61388963:_____/08:00312673!RIV09-MZ0-61388963" . . . "Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir"@en . . "Ko\u017E\u00ED\u0161ek, Milan" . . "Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir"@en . "000258651900010" .