"A novel modular, efficient and practical methodology for the preparation of 3- and 4-substituted phenyl and aniline C-ribonucleosides was developed. The key intermediates were synthesized in two steps from TBS-protected ribonolactone in 75% and 66% yields, respectively, as pure beta-anomers. The bromophenyl intermediates were subjected to a series of palladium catalyzed cross-coupling, aminations and alkoxylation reactions to give, after deprotection a series of free 1 beta-(3- and 4-alkyl, -aryl, -amino -alkoxyphenyl and -hetaryl substituted phenyl)-C-ribonucleosides (20 examples)." . . "Chemistry of Nucleic Acid Components" . "A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides" . "978-80-86241-29-6" . "RIV/61388963:_____/08:00309932!RIV09-AV0-61388963" . "2"^^ . . "RIV/61388963:_____/08:00309932" . . "P(LC512), Z(AV0Z40550506)" . . "A novel modular, efficient and practical methodology for the preparation of 3- and 4-substituted phenyl and aniline C-ribonucleosides was developed. The key intermediates were synthesized in two steps from TBS-protected ribonolactone in 75% and 66% yields, respectively, as pure beta-anomers. The bromophenyl intermediates were subjected to a series of palladium catalyzed cross-coupling, aminations and alkoxylation reactions to give, after deprotection a series of free 1 beta-(3- and 4-alkyl, -aryl, -amino -alkoxyphenyl and -hetaryl substituted phenyl)-C-ribonucleosides (20 examples)."@en . "cross-coupling reactions; C-nucleosides; amination reactions; benzenes"@en . "Modul\u00E1rn\u00ED metodika na p\u0159\u00EDpravu 3- a 4- substituovan\u00FDch benzenov\u00FDch a anil\u00EDnov\u00FDch C-ribonukleosid\u016F"@cs . . . "354261" . . "[DAF95EADA231]" . . "Praha" . . "2008-06-08+02:00"^^ . "A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides"@en . "000257885700112" . . . "Modul\u00E1rn\u00ED metodika na p\u0159\u00EDpravu 3- a 4- substituovan\u00FDch benzenov\u00FDch a anil\u00EDnov\u00FDch C-ribonukleosid\u016F"@cs . . "Hocek, Michal" . . "Byla vyvinuta nov\u00E1 modul\u00E1rn\u00ED, efektivn\u00ED a praktick\u00E1 synt\u00E9za 3- a 4-substituovan\u00FDch fenylov\u00FDch a anilinov\u00FDch C-ribonukleosid\u016F. Oba kl\u00ED\u010Dov\u00E9 intermedi\u00E1ty byly syntetizov\u00E1ny ve dvou kroc\u00EDch, vych\u00E1zej\u00EDc\u00ED z TBS-chr\u00E1n\u011Bn\u00E9ho ribonolaktonu, v 75% a 66% v\u00FDt\u011B\u017Eku jako \u010Dist\u00E9 beta-anomery. 3- a 4-bromfenylov\u00E9 intermedi\u00E1ty p\u0159etransformovan\u00E9 pomoc\u00ED palladiem katalyzovan\u00FDch cross-coupling, amina\u010Dn\u00EDch a alkoxyla\u010Dn\u00EDch reakc\u00ED, poskytly po n\u00E1sledn\u00E9 deprotekci voln\u00E9 1 beta-(3- a 4-alkyl, -aryl, -amino, -alkoxyfenyl a -hetaryl substituovan\u00E9 fenyl)-C-ribonukleosidy (20 p\u0159\u00EDklad\u016F)."@cs . . . "2"^^ . "Institute of Organic Chemistry and Biochemistry ASCR" . . "A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides" . "\u0160tefko, Martin" . . "\u010Cesk\u00FD Krumlov" . "A modular methodology for the synthesis of 3- and 4- substituted benzene and aniline C-ribonucleosides"@en . . "2"^^ . . .