"Chemistry of Nucleic Acid Components" . "Direct C-H arylation of purines and purine nucleosides" . "2"^^ . . "978-80-86241-29-6" . "RIV/61388963:_____/08:00309916!RIV09-AV0-61388963" . "\u010Cer\u0148a, Igor" . . . "P\u0159\u00EDm\u00E1 C-H arylace purin\u016F a purinov\u00FDch nukleosid\u016F"@cs . . . "C-H activation; nucleosides; cross-coupling"@en . . "Direct C-H arylation of purines and purine nucleosides"@en . . "Praha" . . . . . "Direct C-H arylation of purines and purine nucleosides" . . . "2008-06-08+02:00"^^ . "Direct C-H arylation of purines and purine nucleosides"@en . "RIV/61388963:_____/08:00309916" . . . "000257885700065" . . . "Direct C\u2013H arylation of purines to position 8 by diverse aryl halides was achieved using Pd catalysis in the presence of CuI and Cs2CO3. The methodology was applied in consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reaction. In addition, direct arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow straightforward single-step introduction of diverse aryl groups." . "3"^^ . "Hocek, Michal" . "363730" . "Institute of Organic Chemistry and Biochemistry ASCR" . "[95CDAD731B27]" . . "P(GA203/05/0043), P(LC06077), Z(AV0Z40550506)" . "Direct C\u2013H arylation of purines to position 8 by diverse aryl halides was achieved using Pd catalysis in the presence of CuI and Cs2CO3. The methodology was applied in consecutive regioselective synthesis of 2,6,8-trisubstituted purines bearing three different C-substituents in combination with two cross-coupling reaction. In addition, direct arylation of unprotected purine nucleosides with aryl iodides at position 8 was developed to allow straightforward single-step introduction of diverse aryl groups."@en . . "2"^^ . "\u010Cesk\u00FD Krumlov" . "P\u0159\u00EDm\u00E1 C-H arylace purin\u016F a purinov\u00FDch nukleosid\u016F"@cs . "Bylo dosa\u017Eeno p\u0159\u00EDm\u00E9 C-H arylace purin\u016F v poloze 8 r\u016Fzn\u00FDmi aryl halidy pomoc\u00ED palladiov\u00E9 katal\u00FDzy za p\u0159\u00EDtomnosti CuI a Cs2CO3. Tato metoda, v kombinaci se dv\u011Bma cross-coupling reakcemi, byla aplikov\u00E1na v postupn\u00E9 regioselektivn\u00ED synt\u00E9ze 2,6,8-trisubstituovan\u00FDch purin\u016F nesouc\u00EDch t\u0159i odli\u0161n\u00E9 C-substituenty. Byla vyvinuta metoda p\u0159\u00EDm\u00E9 arylace nechr\u00E1n\u011Bn\u00FDch purinov\u00FDch nukloesid\u016F aryl jodidy umo\u017E\u0148uj\u00EDc\u00ED jednokrokov\u00E9 zaveden\u00ED arylov\u00E9 skupiny."@cs . .