. "2008-06-08+02:00"^^ . . "Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis."@en . "P\u0159\u00EDprava modifikovan\u00FDch nukleosid\u016F, nukleotid\u016F a oligonukleotid\u016F nesouc\u00EDch komplexy kov\u016F"@cs . "P(GA203/05/0043), P(LC512), Z(AV0Z40550506)" . "000257885700028" . . . . . . "Hocek, Michal" . . "Institute of Organic Chemistry and Biochemistry ASCR" . "4"^^ . "Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes" . . . "[76883894262D]" . . . "\u010Cesk\u00FD Krumlov" . "RIV/61388963:_____/08:00309908!RIV09-AV0-61388963" . "Byla p\u0159ipravena s\u00E9rie modifikovan\u00FDch nucleosid\u016F a oligonukleotid\u016F nesouc\u00EDch komplexy kov\u016F. Pal\u00E1diem katalyzovan\u00E9 cross-coupling reakce byly kl\u00ED\u010Dov\u00FDm krokem p\u0159i synt\u00E9ze modifikovan\u00FDch kovem-zna\u010Den\u00FDch nukleosid\u016F, nukleotid\u016F a oligonukleotid\u016F. P\u0159\u00EDslu\u0161n\u00E9 Fc modifikovan\u00E9 nukleosid trifosf\u00E1ty byly dobr\u00FDmi substr\u00E1ty DNA polymer\u00E1z a byly \u00FAsp\u011B\u0161n\u011B zabudov\u00E1ny do DNA pomoc\u00ED primer extenze (PEX). Takto modifikovan\u00E9 nukleov\u00E9 kyseliny jsou pou\u017Eiteln\u00E9 jako n\u00E1stroje pro bioanal\u00FDzu."@cs . "2"^^ . . "398784" . "Chemistry of Nucleic Acid Components" . "Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes"@en . "DNA; electrochemical labels; metal complexes"@en . "2"^^ . "RIV/61388963:_____/08:00309908" . "978-80-86241-29-6" . . . "Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes"@en . . "Synthesis of modified nucleosides. Nucleotides and oligonucleotides bearing metal complexes" . . "Praha" . "P\u0159\u00EDprava modifikovan\u00FDch nukleosid\u016F, nukleotid\u016F a oligonukleotid\u016F nesouc\u00EDch komplexy kov\u016F"@cs . . . "Series of modified nucleosides and oligonucleotides bearing metal complexes were synthetized. Palladium catalyzed aqueous-phase cross-coupling reactions were used as key step in the synthesis of modified metallo-labeled nucleosides, nucleotides and oligonucleotides. The corresponding Fc modified dNTPs were good sustrates for DNA polymerases and were efficiently incorporated to DNA by primer extension (PEX). The modified nucleic acids are applicable as tools in bioanalysis." . "Vr\u00E1bel, Milan" . .