"Urban, Milan" . . . "modular methodology; C-2'-deoxyribonucleosides; benzene; pyridin; thiophenyl"@en . . "Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides"@en . "4"^^ . . . "Joubert, Nicolas" . "4"^^ . . "380263" . . . "RIV/61388963:_____/08:00309902!RIV09-AV0-61388963" . "Chemistry of Nucleic Acid Components" . . "Hocek, Michal" . "P(LC512), Z(AV0Z40550506)" . . . . . "Institute of Organic Chemistry and Biochemistry ASCR" . "Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides" . . "978-80-86241-29-6" . "Byla vyvinuta modul\u00E1rn\u00ED metodika pro p\u0159\u00EDpravu r\u016Fzn\u011B substituovan\u00FDch aryl C-2\u00B4-deoxyribonukleosid\u016F. V ka\u017Ed\u00E9 s\u00E9rii byla vypracov\u00E1na syntetick\u00E1 metodika pro multi-gramovou p\u0159\u00EDpravu kl\u00ED\u010Dov\u00E9ho halogenovan\u00E9ho intermedi\u00E1tu, kter\u00FD byl n\u00E1sledn\u011B p\u0159etransformov\u00E1n pomoc\u00ED cross-coupling reakc\u00ED na p\u0159\u00EDslu\u0161n\u00E9 alkyl, aryl a amino substituovan\u00E9 deriv\u00E1ty. N\u00E1sledn\u00E9 odchr\u00E1n\u011Bn\u00ED poskytlo po\u017Eadovan\u00E9 voln\u00E9 C-2\u00B4-deoxyribonukleosidy. Tato metodika byla aplikov\u00E1na pro modul\u00E1rn\u00ED synt\u00E9zu 4- nebo 3-substituovan\u00FDch benzen C-nukleosid\u016F, 6-substituovan\u00FDch pyridin-2-yl C-nukleosid\u016F, 6-substituovan\u00FDch pyridin-3-yl C-nukleosid\u016F a 5-substituovan\u00FDch thiofen-2-yl C-nukleosid\u016F."@cs . . "Modul\u00E1rn\u00ED metodiky pro p\u0159\u00EDpravu r\u016Fzn\u00FDch aryl C-2'-deoxyribonukleosid\u016F"@cs . . . "A modular methodology for the syntheses of various substituted aryl C-2\u00B4-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2\u00B4-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides."@en . "[DF7EEC16AB62]" . "Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides" . "2008-06-08+02:00"^^ . "B\u00E1rta, Jan" . "\u010Cesk\u00FD Krumlov" . . "000257885700026" . "Modular methodology for the synthesis of various aryl C-2'-deoxyribonucleosides"@en . "5"^^ . . "A modular methodology for the syntheses of various substituted aryl C-2\u00B4-deoxyribonucleosides has been developed. In each series, a larger scale synthesis of a versatile halogenated C-nucleoside intermediate has been accomplished, followed by its use for a generation of diverse derivatives by displacement of the halogen for alkyl, aryl or amino substituents by cross-coupling or amination reactions. Subsequent deprotection gave the final desired C-2\u00B4-deoxyribonucleosides. This methodology has been applied for the development of modular syntheses of 4- or 3-substituted benzene C-nucleosides, 6-substituted pyridin-2-yl C-nucleosides, 6-substituted pyridin-3-yl C-nucleosides and 5-substituted thiophen-2-yl C-nucleosides." . "Joubert, Nicolas" . . "Praha" . . "Modul\u00E1rn\u00ED metodiky pro p\u0159\u00EDpravu r\u016Fzn\u00FDch aryl C-2'-deoxyribonukleosid\u016F"@cs . . "RIV/61388963:_____/08:00309902" .