"Esterov\u00E1 profarmaka odvozen\u00E1 od cyklick\u00E9ho 1-(S)-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-azacytosinu: synt\u00E9za a protivirov\u00E1 aktivita"@cs . "RIV/61388963:_____/07:00090983!RIV08-AV0-61388963" . "10"^^ . . "RIV/61388963:_____/07:00090983" . "8"^^ . . "Pohl, Radek" . . . "Andrei, G." . "Byla provedena transformace HPMP-5-azacytosinu na cyklick\u00FD fosfon\u00E1t a jeho n\u00E1sledn\u00E1 reakce s r\u016Fzn\u00FDmi alkylbromidy nebo chlormethylpivalo\u00E1tem p\u0159es tetrabutylammoniovou s\u016Fl jako intermedi\u00E1t. Ve srovn\u00E1n\u00ED s mate\u010Dn\u00FDm HPMP-5-azaC byl u v\u0161ech p\u0159ipraven\u00FDch profarmak zaznamen\u00E1n vzr\u016Fst protivirov\u00E9 aktivity (proti DNA vir\u016Fm). Jako nejaktivn\u011Bj\u0161\u00ED slou\u010Denina se uk\u00E1zal hexadecyloxyethylester cyklick\u00E9ho HPMP-5-azaC."@cs . "0022-2623" . "Naesens, L." . . "Transformation of HPMP-5-azacytosine to the corresponding cyclic phosphonate and its subsequent treatment with various alkyl bromides or chloromethyl pivalate via intermediary tetrabutylammonium salt was performed. Compared to parent HPMP-5-azaC, an increase of antiviral activity (against DNA viruses) was found for all prepared prodrugs. The most active compound was found to be the hexadecyloxyethyl ester of cyclic HPMP-5-azaC." . "Hol\u00FD, Anton\u00EDn" . "Kre\u010Dmerov\u00E1, Marcela" . . "420447" . . "Esterov\u00E1 profarmaka odvozen\u00E1 od cyklick\u00E9ho 1-(S)-[3-hydroxy-2-(fosfonomethoxy)propyl]-5-azacytosinu: synt\u00E9za a protivirov\u00E1 aktivita"@cs . . "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" . "De Clercq, E." . "Transformation of HPMP-5-azacytosine to the corresponding cyclic phosphonate and its subsequent treatment with various alkyl bromides or chloromethyl pivalate via intermediary tetrabutylammonium salt was performed. Compared to parent HPMP-5-azaC, an increase of antiviral activity (against DNA viruses) was found for all prepared prodrugs. The most active compound was found to be the hexadecyloxyethyl ester of cyclic HPMP-5-azaC."@en . "[E062AB000B3F]" . . . . "50" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Journal of Medicinal Chemistry" . . . . . "4"^^ . "Snoeck, R." . "acyclic nucleoside phosphonates; antivirals; HPMP-5-azacytosine; alkoxyalkyl ester; hexadecyloxyethyl ester"@en . . "23" . "Masoj\u00EDdkov\u00E1, Milena" . "P(1M0508), P(1QS400550501), Z(AV0Z40550506)" . "Balzarini, J." . . "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity"@en . "Neyts, J." . . . . "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity"@en . . "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" . . "5765;5772" .