. "9"^^ . "RIV/61388963:_____/06:00053658" . . "0006-2960" . . "Biochemistry" . "Mare\u0161, Michael" . "P(1P04OCB20.002), P(IAA4055303), Z(AV0Z40550506)" . "Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core"@en . "Vondr\u00E1\u0161ek, Ji\u0159\u00ED" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "Je\u017Eek, Jan" . . . "M\u00E1\u0161a, Martin" . . . . "Propeptid blokuje aktivn\u00ED m\u00EDsto inaktivn\u00EDho zymogenu katepsinu D a je vy\u0161t\u011Bpov\u00E1n b\u011Bhem zr\u00E1n\u00ED. Testovali jsme sadu peptidov\u00FDch fragment\u016F odvozen\u00FDch od propeptidu a v kinetick\u00E9m aktivitn\u00EDm testu se zral\u00FDm katepsinem D jsme ur\u010Dili jejich inhibi\u010Dn\u00ED potenci\u00E1l a mod inhibice. Fragment odvozen\u00FD od N-konce propeptidu vykazoval nejv\u011Bt\u0161\u00ED inhibici. Zkoumali jsme vliv sulfatovan\u00FDch glykosaminoglykan\u016F a peptidov\u00FDch mutac\u00ED."@cs . . "15474;15482" . "467872" . "Propeptid katepsinu D: mechanismus a regulace jakointerakce s katalytick\u00FDm j\u00E1drem"@cs . . . . . "45" . . . "The propeptide blocks the active site of inactive zymogen of cathepsin D and is cleaved off during maturation. We tested set of peptidic fragments derived from the propeptide and evaluated their inhibitory potency and mode of inhibition against mature cathepsin D using kinetic activity assay. Fragment derived from the propeptide N-terminus displayed major inhibition. We investigated influence of sulfated glycosaminoglycans and propeptide mutations."@en . . . "Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core" . . . "Propeptid katepsinu D: mechanismus a regulace jakointerakce s katalytick\u00FDm j\u00E1drem"@cs . "Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core"@en . "51" . "6"^^ . . "Cathepsin D propeptide: Mechanism and Regulation of its interaction with the catalytic core" . "[EC09E2A41460]" . "RIV/61388963:_____/06:00053658!RIV07-AV0-61388963" . "The propeptide blocks the active site of inactive zymogen of cathepsin D and is cleaved off during maturation. We tested set of peptidic fragments derived from the propeptide and evaluated their inhibitory potency and mode of inhibition against mature cathepsin D using kinetic activity assay. Fragment derived from the propeptide N-terminus displayed major inhibition. We investigated influence of sulfated glycosaminoglycans and propeptide mutations." . "6"^^ . . "Horn, Martin" . "cathepsin D; propeptide; inhibition"@en . . "Mare\u0161ov\u00E1, Lucie" .