"RIV/61388963:_____/06:00043419" . . "Candida albicans; Candida parapsilosis; Candida inhibitors; secreted aspartic protease"@en . . "RIV/61388963:_____/06:00043419!RIV07-AV0-61388963" . "Srovn\u00E1n\u00ED specifit a struktur sekretovan\u00FDch aspart\u00E1tov\u00FDch proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomoc\u00ED peptidomimetick\u00FDch inhibitor\u016F a homologn\u00EDho modelov\u00E1n\u00ED"@cs . . . "502016" . . "Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling"@en . . "Majer, F." . . . "Hradilek, Martin" . . . . "Biological Chemistry" . "Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling" . . . "Hru\u0161kov\u00E1, Olga" . "Pavl\u00ED\u010Dkov\u00E1, Libu\u0161e" . . . "Pichov\u00E1, Iva" . "Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling"@en . . . "Srovn\u00E1n\u00ED specifit a struktur sekretovan\u00FDch aspart\u00E1tov\u00FDch proteas z Candidy parapsilosis, Candidy albicans a Candidy tropicalis pomoc\u00ED peptidomimetick\u00FDch inhibitor\u016F a homologn\u00EDho modelov\u00E1n\u00ED"@cs . . "Majer, P." . . "387" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "P(GA303/04/0432), P(LC531), Z(AV0Z40550506)" . . "Structure-based specificity mapping of secreted aspartic proteases of Candida parapsilosis, Candida albicans, and Candida tropicalis using peptidomimetic inhibitors and homology modeling" . "1247;1254" . "5"^^ . "Aspart\u00E1tov\u00E9 proteasy sekretovan\u00E9 C. albicans (Sap2p), C. tropicalis (Sapt1p) a C. parapsilosis (Sapp1p) byly purifikov\u00E1ny a testov\u00E1ny se s\u00E9ri\u00ED r\u016Fzn\u011B modifikovan\u00FDch peptidomimetick\u00FDch inhibitor\u016F. Vybran\u00E9 l\u00E1tky inhibovaly proteasy v nanomol\u00E1rn\u00EDch koncentrac\u00EDch. Srovn\u00E1n\u00ED prim\u00E1rn\u00EDch struktur a homologn\u00ED modelov\u00E1n\u00ED struktury (Sapp1p) se zn\u00E1m\u00FDmi strukturami Sapt1p a komplexu inhibitoru se Sap2p umo\u017Enily identifikovat strukturn\u00ED prvky odpov\u011Bdn\u00E9 za rozd\u00EDlnou inhibici jednotliv\u00FDch proteas."@cs . "Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition." . "7"^^ . "9" . . . "1431-6730" . "Dolej\u0161\u00ED, Elena" . "Aspartic proteases secreted by C. albicans (Sap2p), C. tropicalis (Sapt1p), and C. parapsilosis (Sapp1p) were purified and tested for inhibition with a series of peptidomimetic inhibitors with different modifications. Selected compounds inhibited proteases in nanomolar concentration. The sequence alignment of Sap2p, Sapt1p, and Sapp1p and homology modeling of Sapp1p with the crystal structure of Sapt1p and the complex of Sap2p with a peptidomimetic inhibitor identified structural differences, which lead to different susceptibility of individual proteases to inhibition."@en . . "8"^^ . "[2C6C8438B73F]" .