"P(IAA400550510), Z(AV0Z4055905)" . "Unexpectedly strong energy stabilization inside the hydrophobic core of small protein Rubredoxin mediated by aromatic residues: correlated ab initio quantum chemical calculations"@en . . "4"^^ . "Unexpectedly strong energy stabilization inside the hydrophobic core of small protein Rubredoxin mediated by aromatic residues: correlated ab initio quantum chemical calculations" . "hydrophobic core; globular proteins; stabilization"@en . "4"^^ . "Klus\u00E1k, Vojt\u011Bch" . . "547841" . "127" . . . "[3C72B1EB9C54]" . . "Vondr\u00E1\u0161ek, Ji\u0159\u00ED" . "The formation of a hydrophobic core of globular proteins is believed to be the consequence of exterior hydrophobic forces of entropic nature. This, together with the low occurrence of hydrogen bonds in the protein core, leads to the opinion that the energy contribution of core formation to protein folding and stability is negligible. We show that stabilization inside the hydrophobic core of a small protein, rubredoxin, determined by means of high-level correlated ab initio calculations." . "0002-7863" . . . "Journal of the American Chemical Society" . . "Bendov\u00E1, Lada" . . . . "2615;2619" . "RIV/61388963:_____/05:00027136" . "8" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . . "Vyj\u00EDme\u010Dn\u011B siln\u00E1 energetick\u00E1 stabilizace uvnit\u0159 hydrofobn\u00EDho j\u00E1dra Rubredoxinu zprost\u0159edkovan\u00E1 aromatick\u00FDmi aminokyselinami. V\u00FDpo\u010Dty kvantov\u011B chemick\u00FDmi metodami ab initio"@cs . "Unexpectedly strong energy stabilization inside the hydrophobic core of small protein Rubredoxin mediated by aromatic residues: correlated ab initio quantum chemical calculations"@en . . "Vytv\u00E1\u0159en\u00ED hydrofobn\u00EDho j\u00E1dra v globul\u00E1rn\u00EDch proteinech je podle sou\u010Dasn\u00FDch p\u0159edstav d\u016Fsledkem hydrofobn\u00EDch sil entropick\u00E9ho charakteru. Tento fakt spole\u010Dn\u011B s n\u00EDzk\u00FDm v\u00FDskytem vod\u00EDkov\u00FDch m\u016Fstk\u016F v nitru proteinu podporuje n\u00E1zor, \u017Ee energetick\u00FD p\u0159\u00EDsp\u011Bvek stabilizace j\u00E1dra v procesu sbalov\u00E1n\u00ED a stabilizace protein\u016F je zanedbateln\u00FD. V publikovan\u00E9 studii je uk\u00E1z\u00E1no, \u017Ee tento p\u0159\u00EDsp\u011Bvek je nejen podstatn\u00FD, ale je na \u00FArovni pr\u016Fm\u011Brn\u00E9 vod\u00EDkov\u00E9 vazby. Dohromady p\u0159isp\u00EDvaj\u00ED aminokyseliny hydrofobn\u00EDho j\u00E1dra celkovou stabilizac\u00ED asi 50 kcal/mol."@cs . "Vyj\u00EDme\u010Dn\u011B siln\u00E1 energetick\u00E1 stabilizace uvnit\u0159 hydrofobn\u00EDho j\u00E1dra Rubredoxinu zprost\u0159edkovan\u00E1 aromatick\u00FDmi aminokyselinami. V\u00FDpo\u010Dty kvantov\u011B chemick\u00FDmi metodami ab initio"@cs . . . "Hobza, Pavel" . . . "RIV/61388963:_____/05:00027136!RIV06-AV0-61388963" . . "The formation of a hydrophobic core of globular proteins is believed to be the consequence of exterior hydrophobic forces of entropic nature. This, together with the low occurrence of hydrogen bonds in the protein core, leads to the opinion that the energy contribution of core formation to protein folding and stability is negligible. We show that stabilization inside the hydrophobic core of a small protein, rubredoxin, determined by means of high-level correlated ab initio calculations."@en . "Unexpectedly strong energy stabilization inside the hydrophobic core of small protein Rubredoxin mediated by aromatic residues: correlated ab initio quantum chemical calculations" . "5"^^ .