"2"^^ . . "2"^^ . "2"^^ . "387;388" . . "Chalupov\u00E1, \u0160\u00E1rka" . "Synt\u00E9za N4-substituovan\u00FDch deriv\u00E1t\u016F 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide)"@cs . . "1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) je \u00FA\u010Dinn\u00FD v\u016F\u010Di \u0161irok\u00E9mu spektru DNA vir\u016F. Jako VireadTM se pou\u017E\u00EDv\u00E1 pro l\u00E9\u010Dbu cytomegalovirov\u00E9 retinitidy u pacient\u016F s AIDS. Na z\u00E1klad\u011B \u00FA\u010Dink\u016F HPMPC byl zkoum\u00E1n efekt substituce aminofunkce v poloze 4 cytosinov\u00E9 baze na protivirovou aktivitu."@cs . . . "RIV/61388963:_____/05:00022897" . "Chemistry of Nucleic Acid Components" . "80-86241-25-4" . . "P(1M0508), Z(AV0Z40550506)" . "Synt\u00E9za N4-substituovan\u00FDch deriv\u00E1t\u016F 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide)"@cs . "\u00DAstav organick\u00E9 chemie a biochemie AV \u010CR" . "[974D539D861F]" . . "HPMPC; ANP; antivirals"@en . . . . "Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide)"@en . "Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide)"@en . . . "\u0160pindler\u016Fv Ml\u00FDn" . "1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity." . "545755" . . . "Praha" . "Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide)" . . "RIV/61388963:_____/05:00022897!RIV06-MSM-61388963" . . . "1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity."@en . "2005-09-03+02:00"^^ . . "Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide)" . "Hol\u00FD, Anton\u00EDn" . .