. "Turk, B." . "Activation processing of cathepsin H impairs recognition by its propeptide" . . "Biological Chemistry" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . . . "We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide." . . "-" . "P(GP203/01/D008), P(IAA4055303), P(LC512), Z(AV0Z40550506)" . "RIV/61388963:_____/05:00021256!RIV06-MSM-61388963" . "941;947" . . . . "We studied the inhibitory interaction of cathepsin H with its propeptide fragments using the fully processed wild-type enzyme and the recombinant enzyme lacking the mini-chain. The difference between both enzymes with respect to propeptide recognition suggests a structural rearrangement in the cathepsin H molecule induced by maturation processing. The acquired changes, dominated by the mini-chain formation, impair the effective recognition of the mature cathepsin H by its own propeptide."@en . "Horn, Martin" . . . "Baudy\u0161, Miroslav" . "Aktiva\u010Dn\u00ED procesing kathepsinu H br\u00E1n\u00ED interakci s propeptidem"@cs . . "Mare\u0161ov\u00E1, Lucie" . "aminopeptidase; cysteine peptidase; inhibition"@en . . "7"^^ . . . "Studovali jsme inhibi\u010Dn\u00ED interakci fragment\u016F propeptidu se zral\u00FDm kathepsinem H a rekombinantn\u00EDm kathepsinem H, kter\u00FD neobsahuje mini\u0159et\u011Bzec. Rozd\u00EDl v interakci u obou enzym\u016F ukazuje, \u017Ee v molekule kathepsinu H prob\u00EDhaj\u00ED strukturn\u00ED zm\u011Bny indukovan\u00E9 b\u011Bhem zr\u00E1n\u00ED, zejm\u00E9na tvorba mini\u0159et\u011Bzce. Tyto zm\u011Bny br\u00E1n\u00ED \u00FA\u010Dinn\u00E9 inhibici zral\u00E9ho kathepsinu H jeho vlastn\u00EDm propeptidem."@cs . "RIV/61388963:_____/05:00021256" . "511304" . . . "Activation processing of cathepsin H impairs recognition by its propeptide"@en . . . "Activation processing of cathepsin H impairs recognition by its propeptide"@en . "Rul\u00ED\u0161ek, Lubom\u00EDr" . . . "Gan-Erdene, T." . . "9"^^ . . "Aktiva\u010Dn\u00ED procesing kathepsinu H br\u00E1n\u00ED interakci s propeptidem"@cs . "1431-6730" . . "[A8CD4286F989]" . "6"^^ . "386" . "Mare\u0161, Michael" . . "Vasiljeva, O." . "Activation processing of cathepsin H impairs recognition by its propeptide" . "M\u00E1\u0161a, Martin" .