. . "Rosenberg, Ivan" . "Byla studov\u00E1na \u00FA\u010Dinnost difosf\u00E1tu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu (HPMPApp) jako substr\u00E1tu DNA-polymeras. M\u00EDra inkorporace HPMPApp byla vy\u0161\u0161\u00ED pro pol eps\u00EDlon ne\u017E pro pol delta ale 5,4 a\u017E 23 kr\u00E1t ni\u017E\u0161\u00ED ne\u017E inkorporace dATP, co\u017E je nejsp\u00ED\u0161e p\u0159\u00ED\u010Dinou celul\u00E1rn\u00ED toxicity a virostatick\u00E9 aktivity v\u016F\u010Di polyomavir\u016Fm"@cs . "-" . "Otmar, Miroslav" . . "Substr\u00E1tov\u00E1 aktivita difosf\u00E1tu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu k DNA-polymeras\u00E1m alfa, delta a eps\u00EDlon"@cs . . "[C45082C11A3D]" . . "Votruba, Ivan" . "RIV/61388963:_____/04:00100808" . "RIV/61388963:_____/04:00100808!RIV/2005/GA0/A57005/N" . "588942" . "The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon"@en . "0956-3202" . "P(GA203/01/1166), P(IBS4055109), Z(AV0Z4055905)" . . . . "6"^^ . . "HPMPA; cellular DNA polymerases; HPMPC"@en . . "11"^^ . "Rejman, Dominik" . "6"^^ . . "The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon" . "23;33" . "The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon" . . "The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon"@en . . . "Antiviral Chemistry & Chemotherapy" . . "Substr\u00E1tov\u00E1 aktivita difosf\u00E1tu (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adeninu k DNA-polymeras\u00E1m alfa, delta a eps\u00EDlon"@cs . "15" . . . . "Hol\u00FD, Anton\u00EDn" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "In this study the substrate potency of (S)-9-[(3-hydroxy-2-phosphonomethoxy)-propyl]adenine diphosphate (HPMPApp) toward DNA polymerases was examined. It was found that efficiency of HPMPApp incorporation decreased in the order pol epsilon > pol delta and was from 5.4 to 23 fold lower than that of dATP. These observations might contribute to cellular toxicity of HPMPA and explain its antiviral activity against polyomavirus"@en . . . "Birku\u0161, Gabriel" . . . "In this study the substrate potency of (S)-9-[(3-hydroxy-2-phosphonomethoxy)-propyl]adenine diphosphate (HPMPApp) toward DNA polymerases was examined. It was found that efficiency of HPMPApp incorporation decreased in the order pol epsilon > pol delta and was from 5.4 to 23 fold lower than that of dATP. These observations might contribute to cellular toxicity of HPMPA and explain its antiviral activity against polyomavirus" . .