. "H\u00EDve\u0161, J." . . "Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water" . "Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water"@en . "P(GP203/09/P502), Z(AV0Z40400503)" . . "1567-5394" . "Kolivo\u0161ka, Viliam" . "etanidazole; radiosensitizer; electron transfer; voltammetry"@en . . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . "RIV/61388955:_____/10:00335375!RIV11-GA0-61388955" . . "RIV/61388955:_____/10:00335375" . "6"^^ . . "Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water" . . . "Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined." . . . . "G\u00E1l, Miroslav" . . . . "78" . "7"^^ . . . "296690" . . "6"^^ . "Bioelectrochemistry" . "Cytotoxic properties of radiosensitizers are due to the fact that, in the metabolic pathway, these compounds undergo one-electron reduction to generate radical anions. In this study we focused our interest on the electrochemical transfer of the first electron on radiosensitizer Etanidazole (ETN) and, consequently, on the ETN radical-anion formation in the buffered aqueous media. ETN was electrochemically treated in the broad pH range at various scan rates. Three reduction peaks and one oxidation peak were found. At strong alkaline pH the four-electron reduction peak was separated into one-electron and three-electron reductions. Under these conditions the standard rate constant k0 for the redox couple ETN NO2 + e right arrow over left arrow ETN NO2 was calculated. Moreover, the value of a so called E71 potential that accounts for the energy necessary to transfer the first electron to an electroactive group at pH = 7 in aqueous medium to form a radical anion was also determined."@en . . . "2" . "[CBF79F49E822]" . . . "Voltammetry of hypoxic cells radiosensitizer etanidazole radical anion in water"@en . "Bul\u00ED\u010Dkov\u00E1, Jana" . . "Posp\u00ED\u0161il, Lubom\u00EDr" . "000277218900004" . "Hromadov\u00E1, Magdal\u00E9na" . . "Sokolov\u00E1, Romana" .