. . "\u0160enholdov\u00E1, Z." . "113;122" . . "[A224752D36B1]" . . "Pelclov\u00E1, D." . "416963" . . "CZ - \u010Cesk\u00E1 republika" . "RIV/61388955:_____/07:00081282" . . . "Diagnostic Significance of Urinary Thiodiglycolic Acid as a Possible Tool for Studying the Role of Vitamins B12 and Folates in the Metabolism of Thiolic Substances" . "Diagnostick\u00FD v\u00FDznam kyesliny thiodiglykolov\u00E9 v mo\u010Di jako mo\u017En\u00E9ho n\u00E1stroje pro studium role vitaminu B12 a fol\u00E1t\u016F v metabolismu sirn\u00FDch slou\u010Denin"@cs . "Bylo zji\u0161t\u011Bno, \u017Ee stanoven\u00ED kyseliny thiodiglykolov\u00E9 (TDGA) v mo\u010Di m\u016F\u017Ee pomoci charakterizovat nerovnov\u00E1hy l\u00E1tek \u00FA\u010Dastn\u00EDc\u00EDch se na synt\u00E9ze methioninu, kter\u00FD vede k hyperhomocystinurii. V metabolick\u00E9m sch\u00E9matu, zalo\u017Een\u00E9m na vhodn\u00E9 kombinaci zn\u00E1m\u00FDch fakt\u016F, jsme se pokusili teoreticky objasnit a demonstrovat mo\u017Enosti tvorby TDGA r\u016Fzn\u00FDmi cestami p\u0159i transformaci homocysteinu. Toto sch\u00E9ma bylo vyu\u017Eito pro vyhodnocen\u00ED v\u00FDsledk\u016F obdr\u017Een\u00FDch p\u0159i testov\u00E1n\u00ED mo\u010Di \u017Eeny trp\u00EDc\u00ED poruchou funkce methionin synthesy reduktasy. Jej\u00ED nemoc byla ozna\u010Dena jako CblE typ homocystinuriu. Mno\u017Estv\u00ED TDGA vylou\u010Den\u00E9 v jej\u00ED rann\u00ED mo\u010Di urine bylo velmi citliv\u00E9 na zm\u011Bny kombinovan\u00E9 pod\u00E1van\u00FDch N5-formyl tetrahydrofol\u00E1tu, betainu a vitamin B12, kter\u00E9 byly u\u017Eity k jej\u00ED l\u00E9\u010Db\u011B. Vitamin B12 pod\u00E1van\u00FD ve\u010Der samotn\u00FD nebo v kombinaci s betainem zv\u00FD\u0161il vylu\u010Dov\u00E1n\u00ED TDGA v rann\u00ED mo\u010Di a\u017E desetin\u00E1sobn\u011B. Na druh\u00E9 stran\u011B, za nep\u0159\u00EDtomnosti vitaminu B12, betain v kombinaci s N5-formyl tetrahydrofol\u00E1tem br\u00E1n\u00ED v\u00FDskytu TDGA v rann\u00ED mo\u010Di."@cs . "Diagnostic Significance of Urinary Thiodiglycolic Acid as a Possible Tool for Studying the Role of Vitamins B12 and Folates in the Metabolism of Thiolic Substances"@en . . . "8"^^ . . "Diagnostic Significance of Urinary Thiodiglycolic Acid as a Possible Tool for Studying the Role of Vitamins B12 and Folates in the Metabolism of Thiolic Substances"@en . "1" . "P\u0159istoupilov\u00E1, K." . "thiodiglycolic acid (TDGA); homocysteine; urine; voltammetry"@en . . . . "Heyrovsk\u00FD, Michael" . . "We have found that the determination of thiodiglycolic acid (TDGA)in urine may help to characterize metabolic imbalance of substances participating in methionine synthesis, which leads to hyperhomocystinuria. From the metabolic scheme, based on proper combination of know facts, we attempted to theoretically explain and to demonstrate the possibilities of TDGA formation via different ways of homocysteine transformation. This scheme was used in evaluating results obtained from testing urine of a woman suffering from impaired function of methionine synthese reductase. Her disease was declared as CblE type of homocystinuria. The amount of TDGA excreted in her morning urine was very sensitive to changes in combination of N5-formyl tetrahydrofolate, betaine and vitamin B12 used in her treatment. Vitamin B12 given in the evening either alone or together with betaine increased the TDGA excretion in the morning urine up to ten times."@en . . "P\u0159istoupil, T. I." . "RIV/61388955:_____/07:00081282!RIV07-AV0-61388955" . "Diagnostic Significance of Urinary Thiodiglycolic Acid as a Possible Tool for Studying the Role of Vitamins B12 and Folates in the Metabolism of Thiolic Substances" . "10"^^ . "2"^^ . "We have found that the determination of thiodiglycolic acid (TDGA)in urine may help to characterize metabolic imbalance of substances participating in methionine synthesis, which leads to hyperhomocystinuria. From the metabolic scheme, based on proper combination of know facts, we attempted to theoretically explain and to demonstrate the possibilities of TDGA formation via different ways of homocysteine transformation. This scheme was used in evaluating results obtained from testing urine of a woman suffering from impaired function of methionine synthese reductase. Her disease was declared as CblE type of homocystinuria. The amount of TDGA excreted in her morning urine was very sensitive to changes in combination of N5-formyl tetrahydrofolate, betaine and vitamin B12 used in her treatment. Vitamin B12 given in the evening either alone or together with betaine increased the TDGA excretion in the morning urine up to ten times." . . "56" . "Physiological Research" . "P(1H-PK/42), P(NR8107), Z(AV0Z40400503)" . "Navr\u00E1til, Tom\u00E1\u0161" . . "Kohl\u00EDkov\u00E1, E." . "Diagnostick\u00FD v\u00FDznam kyesliny thiodiglykolov\u00E9 v mo\u010Di jako mo\u017En\u00E9ho n\u00E1stroje pro studium role vitaminu B12 a fol\u00E1t\u016F v metabolismu sirn\u00FDch slou\u010Denin"@cs . . "Petr, M." . . . "0862-8408" .