. . "65" . . . "228966" . "Serum concentration of hyaluronic acid correlates with the degree of fibrosis and portal hypertension"@en . "11"^^ . . . "S\u00E9rov\u00E9 hodnoty hyaluronov\u00E9 kyseliny souvisej\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy i port\u00E1ln\u00ED hypertenz\u00ED"@cs . . "P(NT11247), V" . "Jatern\u00ED biopsie je zlat\u00FDm standardem p\u0159i hodnocen\u00ED jatern\u00EDho posti\u017Een\u00ED. Mimo samotnou diagnostiku jatern\u00EDch chorob b\u00FDv\u00E1 c\u00EDlem jatern\u00ED biopsie posoudit z\u00E1n\u011Btlivou aktivitu a stupe\u0148 fibrotizace. V posledn\u00ED dob\u011B jsou vyv\u00EDjeny snahy nahradit jatern\u00ED biopsii neinvazivn\u00EDmi postupy. Se stupn\u011Bm jatern\u00ED fibr\u00F3zy souvis\u00ED n\u011Bkter\u00E9 s\u00E9rov\u00E9 hladiny l\u00E1tek produkovan\u00FDch v procesu fibrotizace, nap\u0159\u00EDklad kyseliny hyaluronov\u00E9 (HA), kter\u00E1 je i sou\u010D\u00E1st\u00ED diagnostick\u00E9ho indexu Hepascore. S\u00E9rov\u00E9 koncentrace HA koreluj\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy u pacient\u016F s chronickou HCV infekc\u00ED, m\u00E9n\u011B informac\u00ED je o jej\u00EDm diagnostick\u00E9m v\u00FDznamu u jin\u00FDch jatern\u00EDch chorob. C\u00EDlem na\u0161\u00ED pr\u00E1ce bylo posoudit diagnostickou hodnotu s\u00E9rov\u00FDch koncentrac\u00ED HA a indexu Hepascore pro ur\u010Den\u00ED stupn\u011B jatern\u00EDf\u00EDbr\u00F3zy \u010Di v\u00FD\u0161e port\u00E1ln\u00ED hypertenze u pacient\u016F s r\u016Fznou etiologi\u00ED jatern\u00EDho po\u0161kozen\u00ED."@cs . "S\u00E9rov\u00E9 hodnoty hyaluronov\u00E9 kyseliny souvisej\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy i port\u00E1ln\u00ED hypertenz\u00ED"@cs . "S\u00E9rov\u00E9 hodnoty hyaluronov\u00E9 kyseliny souvisej\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy i port\u00E1ln\u00ED hypertenz\u00ED" . . . . "7"^^ . "Br\u016Fha, Radan" . . "Urb\u00E1nek, Petr" . . "Serum concentration of hyaluronic acid correlates with the degree of fibrosis and portal hypertension"@en . "Jatern\u00ED biopsie je zlat\u00FDm standardem p\u0159i hodnocen\u00ED jatern\u00EDho posti\u017Een\u00ED. Mimo samotnou diagnostiku jatern\u00EDch chorob b\u00FDv\u00E1 c\u00EDlem jatern\u00ED biopsie posoudit z\u00E1n\u011Btlivou aktivitu a stupe\u0148 fibrotizace. V posledn\u00ED dob\u011B jsou vyv\u00EDjeny snahy nahradit jatern\u00ED biopsii neinvazivn\u00EDmi postupy. Se stupn\u011Bm jatern\u00ED fibr\u00F3zy souvis\u00ED n\u011Bkter\u00E9 s\u00E9rov\u00E9 hladiny l\u00E1tek produkovan\u00FDch v procesu fibrotizace, nap\u0159\u00EDklad kyseliny hyaluronov\u00E9 (HA), kter\u00E1 je i sou\u010D\u00E1st\u00ED diagnostick\u00E9ho indexu Hepascore. S\u00E9rov\u00E9 koncentrace HA koreluj\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy u pacient\u016F s chronickou HCV infekc\u00ED, m\u00E9n\u011B informac\u00ED je o jej\u00EDm diagnostick\u00E9m v\u00FDznamu u jin\u00FDch jatern\u00EDch chorob. C\u00EDlem na\u0161\u00ED pr\u00E1ce bylo posoudit diagnostickou hodnotu s\u00E9rov\u00FDch koncentrac\u00ED HA a indexu Hepascore pro ur\u010Den\u00ED stupn\u011B jatern\u00EDf\u00EDbr\u00F3zy \u010Di v\u00FD\u0161e port\u00E1ln\u00ED hypertenze u pacient\u016F s r\u016Fznou etiologi\u00ED jatern\u00EDho po\u0161kozen\u00ED." . . . "3" . . "1"^^ . . . . "Liver biopsy is a gold standard in the evaluation of liver diseases. Beside the diagnosis of liver diseases, liver biopsy is usually used to assess inflammatory activity and the degree of fibrotisation. Recently, non-invasive parameters have been considered to substitute liver biopsy. The severity of fibrosis correlates with serum concentrations of some substances which are involved in the process of fibrotisation, like hyaluronic acid (HA), which is also part of the diagnostic Hepascore index. Serum concentration of HA was described as elevated in patients with chronic HCV infection; less \u00EDnformation has been published regarding other liver diseases. The aim of our study was: to assess the diagnostic value of serum HA and Hepascore for the evaluation of fibrosis and portal hypertension in patients with liver disease of different aetiology."@en . . "CZ - \u010Cesk\u00E1 republika" . "1804-7874" . "RIV/61383082:_____/11:0074" . "Gastroenterologie a hepatologie" . "[4EB315857DBD]" . "Cirrhosis; liver fibrosis; Hepascore; hyaluronic acid; non-invasive parameters of fibrosis; portal hypertension"@en . "RIV/61383082:_____/11:0074!RIV12-MO0-61383082" . "S\u00E9rov\u00E9 hodnoty hyaluronov\u00E9 kyseliny souvisej\u00ED se stupn\u011Bm jatern\u00ED fibr\u00F3zy i port\u00E1ln\u00ED hypertenz\u00ED" . .