"Celiakie pro praxi"@cs . "6"^^ . . "Celiakie pro praxi"@cs . . "RIV/61383082:_____/11:0043!RIV12-MO0-61383082" . . . . "RIV/61383082:_____/11:0043" . "2"^^ . "1"^^ . "189363" . . "Medicina pro praxi 2011" . "CZ - \u010Cesk\u00E1 republika" . "Celiac disease is a frequent autoimmune disorder of children and adults with world-wide distribution. The prevalence in Czech Republic amounts to 1:200-1:250. In Czech population celiac disease remains underdiagnosed and frequently diagnosed at a late stage. The reasons include an altered phenotype of the disease with frequent extraintestinal symptoms in adults. The manifestation of celiac disease depends on the genetic disposition as well as on the permeability of the intestinal mucosal barrier modulated by the intestinal microbiome and the mucosal immune system. Undiagnosed celiac disease may be a serious condition due to malnutrition, associated autoimmune conditions and life-threatening complications."@en . . . "Celiac Disease for Practice"@en . . . . "2011" . . "I, V" . "1214-8687" . "8" . "[28D2299EA9A9]" . "Fri\u010D, P\u0159emysl" . . "Keil, R." . . . . "Celiakie je \u010Dast\u00E1 autoimunitn\u00ED choroba d\u011Bt\u00ED i dosp\u011Bl\u00FDch ve v\u0161ech zem\u00EDch sv\u011Bta. Jej\u00ED prevalence v \u010Cesk\u00E9 republice se odhaduje na 1:200-1:250. Celiakie je diagnostikov\u00E1na v \u010Desk\u00E9 populaci nedostate\u010Dn\u011B \u010Dasto a naopak \u010Dasto pozd\u011B. P\u0159\u00ED\u010Dinou je zm\u011Bn\u011Bn\u00FD fenotyp s\u00A0\u010Dast\u00FDmi extraintestin\u00E1ln\u00EDmi symptomy u dosp\u011Bl\u00FDch nemocn\u00FDch. Manifestace celiakie z\u00E1vis\u00ED nejen na genetick\u00E9 dispozici, ale tak\u00E9 na funkci st\u0159evn\u00ED slizni\u010Dn\u00ED bari\u00E9ry, jej\u00ED\u017E propustnost je ovlivn\u011Bna st\u0159evn\u00EDm mikrobiomem a slizni\u010Dn\u00EDm imunitn\u00EDm syst\u00E9mem. Nediagnostikovan\u00E1 celiakie je prov\u00E1zena malnutric\u00ED, p\u0159idru\u017Een\u00FDmi autoimunitn\u00EDmi chorobami a komplikacemi, z nich\u017E n\u011Bkter\u00E9 maj\u00ED \u017Eivot ohro\u017Euj\u00EDc\u00ED charakter." . . "Celiakie pro praxi" . "celiac disease; pathogenesis; diagnostics; therapy; prevention; targeted screening"@en . "Celiakie pro praxi" . . "Celiac Disease for Practice"@en . "Celiakie je \u010Dast\u00E1 autoimunitn\u00ED choroba d\u011Bt\u00ED i dosp\u011Bl\u00FDch ve v\u0161ech zem\u00EDch sv\u011Bta. Jej\u00ED prevalence v \u010Cesk\u00E9 republice se odhaduje na 1:200-1:250. Celiakie je diagnostikov\u00E1na v \u010Desk\u00E9 populaci nedostate\u010Dn\u011B \u010Dasto a naopak \u010Dasto pozd\u011B. P\u0159\u00ED\u010Dinou je zm\u011Bn\u011Bn\u00FD fenotyp s\u00A0\u010Dast\u00FDmi extraintestin\u00E1ln\u00EDmi symptomy u dosp\u011Bl\u00FDch nemocn\u00FDch. Manifestace celiakie z\u00E1vis\u00ED nejen na genetick\u00E9 dispozici, ale tak\u00E9 na funkci st\u0159evn\u00ED slizni\u010Dn\u00ED bari\u00E9ry, jej\u00ED\u017E propustnost je ovlivn\u011Bna st\u0159evn\u00EDm mikrobiomem a slizni\u010Dn\u00EDm imunitn\u00EDm syst\u00E9mem. Nediagnostikovan\u00E1 celiakie je prov\u00E1zena malnutric\u00ED, p\u0159idru\u017Een\u00FDmi autoimunitn\u00EDmi chorobami a komplikacemi, z nich\u017E n\u011Bkter\u00E9 maj\u00ED \u017Eivot ohro\u017Euj\u00EDc\u00ED charakter."@cs . .