"Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein" . "22640" . "Rumlov\u00E1, Michaela" . "Dr\u00E1\u017E\u010Fany" . "5"^^ . "ELSO Proceedings" . . "matrix protein, MPMV, Dtyp retrovir\u016F, mutant R55W, NMR experiments, histidine tag"@en . . "Ruml, Tom\u00E1\u0161" . "Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein"@en . . . "Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein" . "RIV/60461373:22640/03:00008458!RIV/2004/GA0/226404/N" . "629279" . "The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV changes its morpho" . . "5"^^ . . "Structure studies of phenotypically relevant mutant of Mason-Pfizer monkey virus matrix protein"@en . "0"^^ . "0"^^ . . "Veverka, V\u00E1clav" . "The Mason-Pfizer Monkey Virus (M-PMV) is a prototype of D-type retroviruses. Morphogenetic pathway of retroviral capsid formation represents the main difference between C- and D- type retroviruses. Unlike the immature capsid of D-type retroviruses is assembled from polyprotein precursors Gag in the specific place in cytoplasm and then transported to the plasma membrane of host cell, the C-type capsid is assembled at the plasma membrane. However, one of the crucial steps of the life cycle of both types of retroviruses is the targeting of polyprotein precursors Gag to the site of assembly. It is known that the matrix protein (MA), which forms the N-terminal part of polyprotein Gag, plays essential role during this process. MA protein plays also a role inother steps of retroviral life cycle - it probably serves as a transport signal of preintegration complex during its targeting to the host nucleus. It was shown that single point mutation in position 55 of the matrix protein of M-PMV changes its morpho"@en . . . "2003-09-20+02:00"^^ . . . . . "GBM" . . . "[F7949CF2F661]" . "0021-9524" . . . . "RIV/60461373:22640/03:00008458" . "Hrabal, Richard" . "281" . . . . "Lipov, Jan" . "Frankfurt/Main" . "P(GA203/03/0490), P(LN00A079), Z(MSM 223300006)" . . "1"^^ . . . . .