. . "Enantioseparation of Tr\u00F6ger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors" . . . . "10.1002/chir.22148" . "Jakubek, Milan" . "Chirality" . . "RIV/60461373:22340/13:43895065" . "22340" . . . "Enantioseparation of Tr\u00F6ger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors"@en . "Havl\u00EDk, Martin" . . . . "0899-0042" . "enantioseparation; cyclodextrins; chiral separation; capillary electrophoresis; Troger's base"@en . "The enantioseparation of seven Troger's base derivatives (TBs) was carried out by capillary electrophoresis using alpha-, beta-, and gamma-cyclodextrins as chiral selectors and phosphate at 20 mmol/l concentration, pH 2.5, as background electrolyte. The method was optimized with respect to the concentration of chosen chiral selectors (0-50 mmol/l) and the amount of organic solvent (acetonitrile, 0-25 % (v/v)) in the electrolyte. The results indicate that all the studied variables, i.e., type of chiral selector, its concentration, and the amount of the added organic solvent, have a significant impact on the enantioseparation of the studied TBs. The best results for the majority of the separated TBs were obtained utilizing beta-cyclodextrin at 5 mmol/l concentration and with various amounts of acetonitrile added ranging from 5 to 15% (v/v) in the background electrolyte. For the two smallest studied TBs, gamma-cyclodextrin with 10% (v/v) acetonitrile also provided good resolution." . . . . . "Enantioseparation of Tr\u00F6ger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors" . . "The enantioseparation of seven Troger's base derivatives (TBs) was carried out by capillary electrophoresis using alpha-, beta-, and gamma-cyclodextrins as chiral selectors and phosphate at 20 mmol/l concentration, pH 2.5, as background electrolyte. The method was optimized with respect to the concentration of chosen chiral selectors (0-50 mmol/l) and the amount of organic solvent (acetonitrile, 0-25 % (v/v)) in the electrolyte. The results indicate that all the studied variables, i.e., type of chiral selector, its concentration, and the amount of the added organic solvent, have a significant impact on the enantioseparation of the studied TBs. The best results for the majority of the separated TBs were obtained utilizing beta-cyclodextrin at 5 mmol/l concentration and with various amounts of acetonitrile added ranging from 5 to 15% (v/v) in the background electrolyte. For the two smallest studied TBs, gamma-cyclodextrin with 10% (v/v) acetonitrile also provided good resolution."@en . "7" . "Enantioseparation of Tr\u00F6ger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors"@en . "5"^^ . "6"^^ . "S\u00FDkora, David" . "6"^^ . "25" . . "\u0158ezanka, Pavel" . . "Ry\u0161av\u00E1, Helena" . "[E1E3154B5EC7]" . . . "Kr\u00E1l, Vladim\u00EDr" . . . . "RIV/60461373:22340/13:43895065!RIV14-GA0-22340___" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "P(GAP206/12/0453)" . "72750" .