"2"^^ . "174991" . "39th International Conference of Slovak Society of Chemical Engineering" . "22340" . "\u0160t\u011Bp\u00E1nek, Franti\u0161ek" . "Slovak Society of Chemical Engineering" . "Transport properties of silica-coated alginate microparticles for controlled delivery"@en . "2012-05-21+02:00"^^ . . . "RIV/60461373:22340/12:43893597!RIV13-MSM-22340___" . "silica-coated alginate microparticles; Transport properties"@en . . "[8BF6A31A3F84]" . "RIV/60461373:22340/12:43893597" . . . . . "Transport properties of silica-coated alginate microparticles for controlled delivery" . . "978-80-89475-04-9" . "Haufov\u00E1, Petra" . "The aim of this work is to produce silica-coated alginate microparticles with specific controllable shell structure for applications in drug and other chemicals delivery. The microparticles were synthesis in two steps [1, 2]. In the first step, alginate gel core were prepared by the drop-on-demand inkjet technology and in the second step the organo-silica shell has been formed by a sol-gel process using alkoxysilane precursors. Using this method, after hydrolysis and polycondensation of precursors, a thin (~1 m\u00FDm) silica shell precipitates on the alginate cores. Furthermore, pre-synthesised silica nanoparticles can be incorporated into the newly formed silica shell. The specific objective of this work is to systematically investigate the transport properties of this layer by measuring the diffusion rates of a range of proteins with increasing molar weight (14 kDa - 66 kDa). Knowledge of the diffusion rate across the silica shell as function of the protein size is a key for the future application of the composite particles as controlled delivery system since the molecular weight cut-off determines the limits on the proteins that can be released from the particles." . "Transport properties of silica-coated alginate microparticles for controlled delivery" . . "Bratislava" . "Transport properties of silica-coated alginate microparticles for controlled delivery"@en . "S" . . "The aim of this work is to produce silica-coated alginate microparticles with specific controllable shell structure for applications in drug and other chemicals delivery. The microparticles were synthesis in two steps [1, 2]. In the first step, alginate gel core were prepared by the drop-on-demand inkjet technology and in the second step the organo-silica shell has been formed by a sol-gel process using alkoxysilane precursors. Using this method, after hydrolysis and polycondensation of precursors, a thin (~1 m\u00FDm) silica shell precipitates on the alginate cores. Furthermore, pre-synthesised silica nanoparticles can be incorporated into the newly formed silica shell. The specific objective of this work is to systematically investigate the transport properties of this layer by measuring the diffusion rates of a range of proteins with increasing molar weight (14 kDa - 66 kDa). Knowledge of the diffusion rate across the silica shell as function of the protein size is a key for the future application of the composite particles as controlled delivery system since the molecular weight cut-off determines the limits on the proteins that can be released from the particles."@en . . . "Tatransk\u00E9 Matliare" . "2"^^ . . . . "5"^^ . .