. "Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression" . "10.1016/j.ejmech.2011.01.032" . . . "Cobalt bis(dicarbollide) derivatives are promising therapeutic agents however their utilization is complicated due to their low solubility and self-assembling in water. Earlier we have shown that their solubility can be increased by using of suitable biocompatible excipients - carriers of pharmaceutically active compounds. Expected mechanism of solubilization was disassembling of self-assemblies and complexation of unimers. Newly our results of time-dependent light scattering study correct this presumption. Poor solubility of all derivatives can be easily improved by using various excipients, however only heptakis(2,6-di-O-methyl)-beta-cyclodextrin displays ability to disassemble self-assemblies of all derivatives and suppress their self-assembling. Surprisingly, the other excipients participate on formation of mixed assemblies of derivative/excipient complex or cover assemblies to make them more soluble without decreasing their size." . "0223-5234" . "European Journal of Medicinal Chemistry" . . "46" . . . . "Rak, Jakub" . . . "Kr\u00E1l, Vladim\u00EDr" . "Jakubek, Milan" . . "Cobalt bis(dicarbollide) derivatives are promising therapeutic agents however their utilization is complicated due to their low solubility and self-assembling in water. Earlier we have shown that their solubility can be increased by using of suitable biocompatible excipients - carriers of pharmaceutically active compounds. Expected mechanism of solubilization was disassembling of self-assemblies and complexation of unimers. Newly our results of time-dependent light scattering study correct this presumption. Poor solubility of all derivatives can be easily improved by using various excipients, however only heptakis(2,6-di-O-methyl)-beta-cyclodextrin displays ability to disassemble self-assemblies of all derivatives and suppress their self-assembling. Surprisingly, the other excipients participate on formation of mixed assemblies of derivative/excipient complex or cover assemblies to make them more soluble without decreasing their size."@en . "4" . . "FR - Francouzsk\u00E1 republika" . . . . "Kapl\u00E1nek, Robert" . "190764" . "Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression"@en . . . . "4"^^ . "[98C42AE5BFD5]" . . . . . "Self-assemblies; Disassembling; Solubilization; Excipients; Cobalt bis(dicarbollide) derivatives"@en . "Mat\u011Bj\u00ED\u010Dek, Pavel" . "Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression" . "RIV/60461373:22340/11:43892252!RIV12-MSM-22340___" . . . "22340" . "RIV/60461373:22340/11:43892252" . "7"^^ . "5"^^ . "Cobalt bis(dicarbollide) derivatives: Solubilization and self-assembly suppression"@en . "P(GA203/09/1311), P(KAN200100801), P(LC512), Z(MSM0021620857)" . . . "000289048400017" .