"12"^^ . "1" . "The evolution of microstructure in three-component granulation and its effect on dissolution" . "The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t" . . "Vznik mikrostruktury ve t\u0159\u00EDslo\u017Ekov\u00E9 granulaci a jej\u00ED vliv na rozpou\u0161t\u011Bn\u00ED"@cs . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . . "The evolution of microstructure in three-component granulation and its effect on dissolution" . "\u0160t\u011Bp\u00E1nek, Franti\u0161ek" . "S" . "Ansari, Mansoor" . "The evolution of microstructure in three-component granulation and its effect on dissolution"@en . "0272-6351" . . "The relationship between microstructure and dissolution rate of three-component granules was investigated. Granules were prepared by fluid bed granulation from sucrose spheres as model excipient, sodium chloride as model active ingredient, and polyethylene glycol (PEG) as in situ melt binder. A novel method for controlling the distribution of active ingredient within the granule was developed, based on suspending its particles in the binder prior to granulation. Granule microstructure was varied by systematically changing the NaCl particle size and the active/excipient ratio in granules. The dissolution rate of granules in water was measured by conductometry. A minimum was found in the functional dependence of dissolution time on NaCl fraction in the granule, in line with earlier computer simulations. The primary particle size was found to influence dissolution time in a nonlinear way depending on the fraction of available particle surface immersed in the binder. The intrinsic binder dissolution can t"@en . "000252356400007" . "366934" . . "dissolution; granulation; melt binder; microstructure; particle size; product design"@en . . "2"^^ . . "1"^^ . . . . . . . "[2A6B45EE55C1]" . "Particulate Science and Technology" . . . "The evolution of microstructure in three-component granulation and its effect on dissolution"@en . "Pr\u00E1ce popisuje experiment\u00E1ln\u00ED studii vlivu slo\u017Een\u00ED a mikrostruktury granul\u00ED obsahuj\u00EDc\u00EDch dva typy prim\u00E1rn\u00EDch \u010D\u00E1stic a pojivo na rychost vylu\u010Dov\u00E1n\u00ED slo\u017Eek a celkovou rychlost rozpou\u0161t\u011Bn\u00ED. Granule byly vytvo\u0159eny ve fluidn\u00EDm granul\u00E1toru a rychlost rozpou\u0161t\u011Bn\u00ED byla studov\u00E1na konduktometricky. Poprv\u00E9 byla experiment\u00E1ln\u011B ov\u011B\u0159ena existence maxima rozpou\u0161t\u011Bc\u00ED rychlosti v z\u00E1vislosti na obsahu aktivn\u00ED slo\u017Eky v granuli."@cs . . "Vznik mikrostruktury ve t\u0159\u00EDslo\u017Ekov\u00E9 granulaci a jej\u00ED vliv na rozpou\u0161t\u011Bn\u00ED"@cs . "RIV/60461373:22340/08:00020747" . . "22340" . "RIV/60461373:22340/08:00020747!RIV09-MSM-22340___" . . "26" .