"2"^^ . . "NL - Nizozemsko" . . . "[6FF30D24B6D1]" . "Granulation; Porosity; Microstructure; Dissolution; Computer simulation; Product design"@en . . "The effect of granule microstructure on dissolution rate" . "181" . . "RIV/60461373:22340/08:00020745!RIV09-MSM-22340___" . "The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have" . "0032-5910" . "365100" . "22340" . "2" . . "The relationship between the microstructure of granules and their dissolution rate has been investigated. Granules consisting of mannitol primary particles and PVP aqueous binder have been prepared by top-spray fluid-bed granulation, and granules consisting of sucrose primary particles and PEG binder by in-situ melt fluid-bed granulation. Granule microstructure has been systematically varied by manipulating the primary particle size distribution and the binder content in each case. In both cases granule porosity was found to be a decreasing function of binder content and a minimum of porosity as function of the fine/coarse primary particle mixing ratio has been observed, in line with theoretical expectations. Granule microstructures have been analysed using X-ray computed micro-tomography and compared with three-dimensional ?virtual granules? generated by a computer simulation of the agglomeration process. The dissolution rate of granules has then been measured. While porosity was found to have"@en . "Vliv mikrostruktury granul\u00ED na rychlost rozpou\u0161t\u011Bn\u00ED"@cs . "The effect of granule microstructure on dissolution rate" . . . "RIV/60461373:22340/08:00020745" . "Powder Technology" . "11"^^ . "000253190200003" . "Ansari, Mansoor" . "The effect of granule microstructure on dissolution rate"@en . . . . . "1"^^ . "\u0160t\u011Bp\u00E1nek, Franti\u0161ek" . "S" . . "Vliv mikrostruktury granul\u00ED na rychlost rozpou\u0161t\u011Bn\u00ED"@cs . "The effect of granule microstructure on dissolution rate"@en . . . . "V t\u00E9to pr\u00E1ci je pops\u00E1na studie vlivu porozity granul\u00ED a obsahu a typu pojiva na rychlost jejich rozpou\u0161t\u011Bn\u00ED. Byly studov\u00E1ny granule dvoj\u00EDho typu ? s pojivem dod\u00E1van\u00FDm jako tavenina a jako roztok. Je uk\u00E1z\u00E1no, \u017Ee pro danou kombinaci prim\u00E1rn\u00EDch \u010D\u00E1stic a materi\u00E1lu pojiva je rozhoduj\u00EDc\u00EDm parametrem pro rozpou\u0161t\u011Bn\u00ED porozita granul\u00ED."@cs . .