"Photochemistry and Photobiology" . . "2" . . . "0031-8655" . . "7"^^ . . . "Kr\u00E1lov\u00E1, J." . . "6"^^ . "489175" . "porphyrin; mono- and bis-b-cyclodextrin derivatives; photodynamic antitumor effect"@en . "Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo"@en . "V p\u0159edstaven\u00E9m studiu byly sledovan\u00E9 fotosensibiln\u00ED vlastnosti dvou nov\u00FDch mono- a bis-cyclodextrin tetrakis(pentafluorofenyl) porfyrinov\u00FDch deriv\u00E1t\u016F na kultur\u00E1ch n\u00E1dorov\u00FDch bun\u011Bk a na n\u00E1doru prsn\u00ED \u017El\u00E1zy 4T1 transplantovan\u00E9ho pod k\u016F\u017Ei BALB/c my\u0161i. Ob\u011B studovan\u00E9 l\u00E1tky v experimentech in vitro prok\u00E1zaly lokalizace v lysosomech bun\u011B\u010Dn\u00FDch kultur a indukovaly smrt bun\u011Bk spou\u0161t\u011Bn\u00EDm apoptosy. Mono-cyclodextrin porfyrinov\u00FD deriv\u00E1t, P(b-CD)1, projevoval siln\u011Bj\u0161\u00ED fotodynamick\u00FD efekt in vitro ne\u017E bis-cyclodextrinov\u00FD derivat P(b-CD)2. Ale v experimentech in vivo P(b-CD)2 uk\u00E1zal rychlej\u0161\u00ED lokalizace v n\u00E1dorov\u00E9 tk\u00E1ni s maxim\u00E1ln\u00ED obsahem u\u017E za 6 hodin po aplikace a siln\u011Bj\u0161\u00ED protin\u00E1dorovou aktivitu na rozd\u00EDl od P(b-CD)1 z pomalej\u0161\u00ED lokalizace."@cs . "In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis(pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing subcutaneously transplanted syngeneic mouse mammary carcinoma, 4T1. Both studied sensitizers were localized mainly into lysosomes and were found to induce cells death by triggering apoptosis in human leukemic cells HL-60. In 4T1 and other cell lines both apoptotic and necrotic modes of cell death occurred dependently on drug and light doses. Mono-cyclodextrin porphyrin derivative, P(b-CD)1, exhibited stronger in vitro photodynamic efficacy than bis-cyclodextrin derivative, P(b-CD)2. However, when their efficacy was evaluated in vivo, P(b-CD)2 displayed faster tumor uptake with maximal accumulation 6 h after application leading to complete and prolonged elimination of subcutaneous tumors within 3 days after irradiation (100 J/cm2). In contrast P(b-CD)1 uptake was slower (48 h) and reduction of tu"@en . "Synytsya, Alla" . "In the present study we investigated photosensitizing properties of two novel mono- and bis-cyclodextrin tetrakis(pentafluorophenyl) porphyrin derivatives in several tumor cell lines and in BALB/c mice bearing subcutaneously transplanted syngeneic mouse mammary carcinoma, 4T1. Both studied sensitizers were localized mainly into lysosomes and were found to induce cells death by triggering apoptosis in human leukemic cells HL-60. In 4T1 and other cell lines both apoptotic and necrotic modes of cell death occurred dependently on drug and light doses. Mono-cyclodextrin porphyrin derivative, P(b-CD)1, exhibited stronger in vitro photodynamic efficacy than bis-cyclodextrin derivative, P(b-CD)2. However, when their efficacy was evaluated in vivo, P(b-CD)2 displayed faster tumor uptake with maximal accumulation 6 h after application leading to complete and prolonged elimination of subcutaneous tumors within 3 days after irradiation (100 J/cm2). In contrast P(b-CD)1 uptake was slower (48 h) and reduction of tu" . "Koc, M." . "Nov\u00E9 porfyrinov\u00E9 conjugaty s fotodynamick\u00FDm protin\u00E1dorov\u00FDm efektem: \u00FA\u010Dinnost mono- a bis-b-cyclodextrinov\u00FDch deriv\u00E1t\u016F v in vivo a in vitro studiu"@cs . "Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo" . . "P(GA301/04/1315), Z(MSM6046137307)" . . "432-438" . "Kr\u00E1l, Vladim\u00EDr" . . "2"^^ . . "Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo"@en . "RIV/60461373:22340/06:00016680" . . "Nov\u00E9 porfyrinov\u00E9 conjugaty s fotodynamick\u00FDm protin\u00E1dorov\u00FDm efektem: \u00FA\u010Dinnost mono- a bis-b-cyclodextrinov\u00FDch deriv\u00E1t\u016F v in vivo a in vitro studiu"@cs . "RIV/60461373:22340/06:00016680!RIV07-MSM-22340___" . "Pou\u010Dkov\u00E1, P." . "[BC8E56058F96]" . "CA - Kanada" . "22340" . "82" . . . "Novel porphyrin conjugates with a potent photodynamic antitumor effect: differential efficacy of mono- and bis-b-cyclodextrin derivatives. In vitro and in vivo" . "Dvo\u0159\u00E1k, M." . . . . .