"4"^^ . . "NMR studie interakce deriv\u00E1t\u016F distamycinu s DNA"@cs . "488737" . . "3"^^ . . "Z(MSM6046137307)" . "A series of novel dimeric distamycin derivatives with increasing number of 1-methylpyrrole units, was synthesized. In comparison with natural distamycin, the dimeric derivatives contain a Tr\u00F6ger base as a bridging unit in the centres of their molecules. The main goal of this work was to study the influence of interaction with calf thymus DNA on the distamycin derivative molecule by 1H NMR spectrometry and to determine the binding site. It was observed that addition of DNA caused broadening of hydrogen signals and also changes in corresponding relaxation times. Both facts are in accordance with the assumed interaction. The results are discussed for dirrerent derivatives in depencence on the possible binding site and compared with those from circular dichroism."@en . "Tkadlecov\u00E1, Marcela" . "RIV/60461373:22340/06:00016633" . . . "Palivec, Luk\u00E1\u0161" . "Kr\u00E1l, Vladim\u00EDr" . . "NMR studie interakce deriv\u00E1t\u016F distamycinu s DNA"@cs . "3" . . "Tr\u00F6ger base; distamycin; DNA; NMR"@en . "210-212" . "22340" . "[806F727AD5C4]" . . . . "Interaction of Novel Dimeric Distamycin Derivatives with DNA: NMR Study"@en . "Chemick\u00E9 listy" . . . . "RIV/60461373:22340/06:00016633!RIV07-MSM-22340___" . "Byla syntetizov\u00E1na \u0159ada nov\u00FDch distamycinov\u00FDch deriv\u00E1t\u016F s rostouc\u00EDm po\u010Dtem 1-melhylpyrolov\u00FDch jednotek. Ve srovn\u00E1n\u00ED s p\u0159\u00EDrodn\u00EDm distamycinem dimern\u00ED deriv\u00E1ty obsahuj\u00ED Tr\u00F6gerovu b\u00E1zi jako spojovac\u00ED \u010D\u00E1st uprost\u0159ed molekuly. Hlavn\u00EDm c\u00EDlem t\u00E9to pr\u00E1ce bylo studovat vliv interakce s DNA z telec\u00EDho brzl\u00EDku na molekule distamycin\u00E1rn\u00EDho deriv\u00E1tu pomoc\u00ED 1/1 NMR spektrometrie a ur\u010Dit vazebn\u00ED misto. Bylo pozorov\u00E1no, \u017Ee p\u0159\u00EDdavky DNA zp\u016Fsobily roz\u0161\u00ED\u0159en\u00ED vod\u00EDkov\u00FDch sign\u00E1l\u016F a zm\u011Bny v odpov\u00EDdaj\u00EDch relaxa\u010Dn\u00EDch \u010Dasech. Oboj\u00ED je ve shod\u011B s p\u0159edpokl\u00E1danou interakc\u00ED. V\u00FDsledky jsou diskutov\u00E1ny pro r\u016Fzn\u00E9 deriv\u00E1ty v z\u00E1vislosti na mo\u017En\u00E9m vazebn\u00E9m m\u00EDst\u011B a srovn\u00E1ny s v\u00FDsledky z cirkul\u00E1rn\u00EDho dichroismu." . "Val\u00EDk, Martin" . "CZ - \u010Cesk\u00E1 republika" . "5"^^ . "Byla syntetizov\u00E1na \u0159ada nov\u00FDch distamycinov\u00FDch deriv\u00E1t\u016F s rostouc\u00EDm po\u010Dtem 1-melhylpyrolov\u00FDch jednotek. Ve srovn\u00E1n\u00ED s p\u0159\u00EDrodn\u00EDm distamycinem dimern\u00ED deriv\u00E1ty obsahuj\u00ED Tr\u00F6gerovu b\u00E1zi jako spojovac\u00ED \u010D\u00E1st uprost\u0159ed molekuly. Hlavn\u00EDm c\u00EDlem t\u00E9to pr\u00E1ce bylo studovat vliv interakce s DNA z telec\u00EDho brzl\u00EDku na molekule distamycin\u00E1rn\u00EDho deriv\u00E1tu pomoc\u00ED 1/1 NMR spektrometrie a ur\u010Dit vazebn\u00ED misto. Bylo pozorov\u00E1no, \u017Ee p\u0159\u00EDdavky DNA zp\u016Fsobily roz\u0161\u00ED\u0159en\u00ED vod\u00EDkov\u00FDch sign\u00E1l\u016F a zm\u011Bny v odpov\u00EDdaj\u00EDch relaxa\u010Dn\u00EDch \u010Dasech. Oboj\u00ED je ve shod\u011B s p\u0159edpokl\u00E1danou interakc\u00ED. V\u00FDsledky jsou diskutov\u00E1ny pro r\u016Fzn\u00E9 deriv\u00E1ty v z\u00E1vislosti na mo\u017En\u00E9m vazebn\u00E9m m\u00EDst\u011B a srovn\u00E1ny s v\u00FDsledky z cirkul\u00E1rn\u00EDho dichroismu."@cs . . . "Folt\u00FDnov\u00E1, Jarmila" . "100" . "Interaction of Novel Dimeric Distamycin Derivatives with DNA: NMR Study"@en . . "NMR studie interakce deriv\u00E1t\u016F distamycinu s DNA" . . . . "NMR studie interakce deriv\u00E1t\u016F distamycinu s DNA" . "0009-2770" .