"[756689798FDB]" . . "5396" . . "Bioavailability and prodrugs of acyclic nucleoside analogs and acyclic nucleoside phosponates"@en . "Acyklick\u00E1 analoga slo\u017Eek nukleov\u00FDch kyselin jsou l\u00E1tky s velmi \u0161irok\u00FDm spektrem \u00FA\u010Dinku. Jejich pou\u017Eit\u00ED p\u0159itom st\u00E1le nar\u00E1\u017E\u00ED na p\u0159ek\u00E1\u017Eky spojen\u00E9 s jejich biologickou dostupnost\u00ED, p\u0159\u00EDpadn\u011B vedlej\u0161\u00EDmi \u00FA\u010Dinky. Tyto probl\u00E9my byly v minulosti \u0159e\u0161eny mimo jin\u00E9 p\u0159\u00EDpravou r\u016Fzn\u00FDch profarmak. Tento \u010Dl\u00E1nek v kostce p\u0159edstavuje v\u00FDb\u011Br pou\u017Eit\u00FDch strategi\u00ED, p\u0159i\u010Dem\u017E pozornost je v\u011Bnov\u00E1na v neposledn\u00ED \u0159ad\u011B biotechnologick\u00FDm \u00FAvah\u00E1m a postup\u016Fm v r\u00E1mci p\u0159\u00EDpravy p\u0159edstaven\u00FDch struktur."@cs . "RIV/60461373:22330/14:43898260" . "Prodrugs, acyclic analogs, nucleosides, nucleotides, acyclic nucleoside phosphonates"@en . . . "CZ - \u010Cesk\u00E1 republika" . . . "RIV/60461373:22330/14:43898260!RIV15-MSM-22330___" . "Acyklick\u00E1 analoga slo\u017Eek nukleov\u00FDch kyselin jsou l\u00E1tky s velmi \u0161irok\u00FDm spektrem \u00FA\u010Dinku. Jejich pou\u017Eit\u00ED p\u0159itom st\u00E1le nar\u00E1\u017E\u00ED na p\u0159ek\u00E1\u017Eky spojen\u00E9 s jejich biologickou dostupnost\u00ED, p\u0159\u00EDpadn\u011B vedlej\u0161\u00EDmi \u00FA\u010Dinky. Tyto probl\u00E9my byly v minulosti \u0159e\u0161eny mimo jin\u00E9 p\u0159\u00EDpravou r\u016Fzn\u00FDch profarmak. Tento \u010Dl\u00E1nek v kostce p\u0159edstavuje v\u00FDb\u011Br pou\u017Eit\u00FDch strategi\u00ED, p\u0159i\u010Dem\u017E pozornost je v\u011Bnov\u00E1na v neposledn\u00ED \u0159ad\u011B biotechnologick\u00FDm \u00FAvah\u00E1m a postup\u016Fm v r\u00E1mci p\u0159\u00EDpravy p\u0159edstaven\u00FDch struktur." . "Biologick\u00E1 dostupnost a prol\u00E9\u010Diva acyklick\u00FDch analog nukleosid\u016F a acyklick\u00FDch nukleosidfosfon\u00E1t\u016F" . . "Biologick\u00E1 dostupnost a prol\u00E9\u010Diva acyklick\u00FDch analog nukleosid\u016F a acyklick\u00FDch nukleosidfosfon\u00E1t\u016F" . "Acyclic analogs of nucleic acids components are compounds with a broad spectrum of action. Their use collides with hurdles associated with their biological availability, or with side effects. In the past, these problems were solved for example by preparation of different prodrugs. This paper presents briefly a selection of used strategies, last but not least with respect to the biotechnological reflections and methods on the field of preparation of the presented structures."@en . . "I" . "Bioprospect" . . "Biologick\u00E1 dostupnost a prol\u00E9\u010Diva acyklick\u00FDch analog nukleosid\u016F a acyklick\u00FDch nukleosidfosfon\u00E1t\u016F"@cs . "Biologick\u00E1 dostupnost a prol\u00E9\u010Diva acyklick\u00FDch analog nukleosid\u016F a acyklick\u00FDch nukleosidfosfon\u00E1t\u016F"@cs . . . "Bioavailability and prodrugs of acyclic nucleoside analogs and acyclic nucleoside phosponates"@en . "1210-1737" . . "2" . "24" . "1"^^ . . . "1"^^ . "Bla\u017Eek, Ji\u0159\u00ED" . . "5"^^ . . "22330" .