"2"^^ . "\u010Cejkov\u00E1, Alena" . . "2014-04-03+02:00"^^ . "Vysok\u00E1 \u0161kola chemicko-technologick\u00E1 v Praze" . . "Nano\u010D\u00E1stice a jejich schopnost stimulace bun\u011B\u010Dn\u00E9ho r\u016Fstu" . . "5"^^ . "Nano\u010D\u00E1stice a jejich schopnost stimulace bun\u011B\u010Dn\u00E9ho r\u016Fstu" . . . . "Nanoparticles and their ability to stimulate the growth of cells"@en . "RIV/60461373:22330/14:43897319" . . . "Nano\u010D\u00E1stice a jejich schopnost stimulace bun\u011B\u010Dn\u00E9ho r\u016Fstu"@cs . . "Nano\u010D\u00E1stice a jejich schopnost stimulace bun\u011B\u010Dn\u00E9ho r\u016Fstu"@cs . . . "22330" . "Nanoparticles and their ability to stimulate the growth of cells"@en . "Praha" . "978-80-7080-884-9" . "S" . . "P\u00E1drov\u00E1, Karol\u00EDna" . "Praha" . "Fyzik\u00E1ln\u011B-chemick\u00E9 vlastnosti nano\u010D\u00E1stic jsou determinov\u00E1ny jejich rozm\u011Bry a jsou p\u0159\u00ED\u010Dinou jejich odli\u0161n\u00E9 biologick\u00E9 aktivity, ne\u017E kterou disponuj\u00ED makroskopick\u00E9 analogy. Vzhledem k pom\u011Brn\u011B rychl\u00E9mu rozvoji nanotechnologi\u00ED povst\u00E1vaj\u00ED ot\u00E1zky t\u00FDkaj\u00EDc\u00ED se vlivu nanomateri\u00E1l\u016F na \u017Eivotn\u00ED prost\u0159ed\u00ED. Sou\u010Dasn\u00FD v\u00FDzkum se zab\u00FDv\u00E1 p\u0159edev\u0161\u00EDm problematikou cytotoxicity, mechanismu p\u016Fsoben\u00ED a mo\u017Enostmi modulace toxick\u00FDch \u00FA\u010Dink\u016F t\u011Bchto l\u00E1tek. Z hlediska mechanismu toxick\u00E9ho p\u016Fsoben\u00ED je kl\u00ED\u010Dov\u00FDm krokem interakce nano\u010D\u00E1stic s bu\u0148kou. Nano\u010D\u00E1stice se ochotn\u011B v\u00E1\u017E\u00ED na bun\u011B\u010Dn\u00FD povrch, co\u017E po expozici vysok\u00FDm koncentrac\u00EDm vede k jeho po\u0161kozen\u00ED a naru\u0161en\u00ED bun\u011B\u010Dn\u00E9 permeability. Naproti t\u00E9to skute\u010Dnosti bylo tak\u00E9 prok\u00E1z\u00E1no, \u017Ee vy\u0161\u0161\u00ED bio-dostupnost nano\u010D\u00E1stic (v n\u00EDzk\u00FDch koncentrac\u00EDch) m\u016F\u017Ee m\u00EDt pro bu\u0148ku tak\u00E9 pozitivn\u00ED \u00FA\u010Dinek. Expozice bun\u011Bk \u0159\u00E1dov\u011B miligramov\u00FDm koncentrac\u00EDm n\u011Bkter\u00FDch typ\u016F nano\u010D\u00E1stic (p\u0159. Fe0, ZnO) se projevila v\u00FDraznou stimulac\u00ED r\u016Fstu. Zd\u00E1 se, \u017Ee nano\u010D\u00E1stice mohou p\u0159edstavovat vhodn\u011Bj\u0161\u00ED zdroj esenci\u00E1ln\u00EDch prvk\u016F nezbytn\u00FDch pro spr\u00E1vnou funkci bun\u011B\u010Dn\u00E9ho metabolismu ne\u017E v p\u0159\u00EDrod\u011B b\u011B\u017En\u011B dostupn\u00E9 slou\u010Deniny. Vyu\u017Eit\u00ED n\u011Bkter\u00FDch typ\u016F nano\u010D\u00E1stic k modifikac\u00EDm kultiva\u010Dn\u00EDho prost\u0159ed\u00ED v biotechnologi\u00EDch by mohlo b\u00FDt cestou k z\u00EDsk\u00E1n\u00ED ekonomicky v\u00FDhodn\u011Bj\u0161\u00EDch produkt\u016F."@cs . "The unique properties of nanoparticles are determinate by their nano-scale. Materials with dimensions lesser than 100 nm have quite different physicochemical properties compared to their conventional counterparts. Increasing use of nanoparticles in practise brings questions which deal with their effect on environment. Many studies have engaged in nanoparticles toxicity, the elucidation of mechanism of action and the possibility of mitigating their toxicity. Mutual interactions between nanoparticles and cells seem to be crucial. Nanoparticles readily absorb on cell surface. Exposition to higher (toxic) concentrations results in membrane disruption and further loss of membrane selective permeability. In contrast, several studies have described that some nanoparticles, such as Fe0, ZnO or TiO2 (at low concentrations) could have positive effect to improve the life functions of various organisms. The considerable bioavailability of nanoparticles supports the hypothesis that they may be a more favourable source of trace elements than the bulk analogues. Application of nanoparticles in this field brings rather new sight on nanotechnology issue and use. Adjusting the culture media with nanoparticles may be a way to obtain economically advantageous products."@en . "31483" . "cells; growth; the; stimulate; ability; their; and; Nanoparticles"@en . "[C1796CA97042]" . . "Sborn\u00EDk souhrn\u016F a pln\u00FDch text\u016F p\u0159\u00EDsp\u011Bvk\u016F konference Kvasn\u00E1 chemie a bioin\u017Een\u00FDrstv\u00ED 2014" . . . "RIV/60461373:22330/14:43897319!RIV15-MSM-22330___" . "2"^^ . . . . . . "Fyzik\u00E1ln\u011B-chemick\u00E9 vlastnosti nano\u010D\u00E1stic jsou determinov\u00E1ny jejich rozm\u011Bry a jsou p\u0159\u00ED\u010Dinou jejich odli\u0161n\u00E9 biologick\u00E9 aktivity, ne\u017E kterou disponuj\u00ED makroskopick\u00E9 analogy. Vzhledem k pom\u011Brn\u011B rychl\u00E9mu rozvoji nanotechnologi\u00ED povst\u00E1vaj\u00ED ot\u00E1zky t\u00FDkaj\u00EDc\u00ED se vlivu nanomateri\u00E1l\u016F na \u017Eivotn\u00ED prost\u0159ed\u00ED. Sou\u010Dasn\u00FD v\u00FDzkum se zab\u00FDv\u00E1 p\u0159edev\u0161\u00EDm problematikou cytotoxicity, mechanismu p\u016Fsoben\u00ED a mo\u017Enostmi modulace toxick\u00FDch \u00FA\u010Dink\u016F t\u011Bchto l\u00E1tek. Z hlediska mechanismu toxick\u00E9ho p\u016Fsoben\u00ED je kl\u00ED\u010Dov\u00FDm krokem interakce nano\u010D\u00E1stic s bu\u0148kou. Nano\u010D\u00E1stice se ochotn\u011B v\u00E1\u017E\u00ED na bun\u011B\u010Dn\u00FD povrch, co\u017E po expozici vysok\u00FDm koncentrac\u00EDm vede k jeho po\u0161kozen\u00ED a naru\u0161en\u00ED bun\u011B\u010Dn\u00E9 permeability. Naproti t\u00E9to skute\u010Dnosti bylo tak\u00E9 prok\u00E1z\u00E1no, \u017Ee vy\u0161\u0161\u00ED bio-dostupnost nano\u010D\u00E1stic (v n\u00EDzk\u00FDch koncentrac\u00EDch) m\u016F\u017Ee m\u00EDt pro bu\u0148ku tak\u00E9 pozitivn\u00ED \u00FA\u010Dinek. Expozice bun\u011Bk \u0159\u00E1dov\u011B miligramov\u00FDm koncentrac\u00EDm n\u011Bkter\u00FDch typ\u016F nano\u010D\u00E1stic (p\u0159. Fe0, ZnO) se projevila v\u00FDraznou stimulac\u00ED r\u016Fstu. Zd\u00E1 se, \u017Ee nano\u010D\u00E1stice mohou p\u0159edstavovat vhodn\u011Bj\u0161\u00ED zdroj esenci\u00E1ln\u00EDch prvk\u016F nezbytn\u00FDch pro spr\u00E1vnou funkci bun\u011B\u010Dn\u00E9ho metabolismu ne\u017E v p\u0159\u00EDrod\u011B b\u011B\u017En\u011B dostupn\u00E9 slou\u010Deniny. Vyu\u017Eit\u00ED n\u011Bkter\u00FDch typ\u016F nano\u010D\u00E1stic k modifikac\u00EDm kultiva\u010Dn\u00EDho prost\u0159ed\u00ED v biotechnologi\u00EDch by mohlo b\u00FDt cestou k z\u00EDsk\u00E1n\u00ED ekonomicky v\u00FDhodn\u011Bj\u0161\u00EDch produkt\u016F." . .