"Mykotoxiny mohou b\u00FDt stejn\u011B jako ostatn\u00ED xenobiotika \u010D\u00E1ste\u010Dn\u011B metabolizov\u00E1ny za vzniku konjugovan\u00FDch forem mykotoxin\u016F. Konjugovan\u00E9 mykotoxiny se mohou vyskytovat bu\u010F ve form\u011B rozpustn\u00E9 (maskovan\u00E9 mykotoxiny) \u010Di asociovan\u00E9 v makromolekule (v\u00E1zan\u00E9 mykotoxiny). Konzumenti jsou tak prost\u0159ednictv\u00EDm potravin kontaminovan\u00FDch mykotoxiny vystaveni jak jejich nativn\u00EDm, tak \u010D\u00E1ste\u010Dn\u011B metabolizovan\u00FDm form\u00E1m. V r\u00E1mci projektu Ministerstva zem\u011Bd\u011Blstv\u00ED \u010CR QI111B044 Komplexn\u00ED strategie pro minimalizaci negativn\u00EDho dopadu infekce toxinogenn\u00EDmi houbami rodu Fusarium v obilovin\u00E1ch a odvozen\u00FDch produktech byly objeveny velmi vysok\u00E9 koncentrace mykotoxin\u016F nivalenolu a zearalenonu ve vzorc\u00EDch je\u010Dmene jarn\u00EDho p\u011Bstovan\u00FDch v lokalit\u00E1ch Krom\u011B\u0159\u00ED\u017E a Lib\u010Dany, dan\u00E9 vzorky byly pak analyzov\u00E1ny na v\u00FDskyt konjugovan\u00FDch forem t\u011Bchto sekund\u00E1rn\u00EDch metabolit\u016F. S vyu\u017Eit\u00EDm vysokorozli\u0161ovac\u00ED hmotnostn\u00ED spektrometrie byly sledov\u00E1ny mo\u017En\u00E9 konjug\u00E1ty nivalenolu a zearalenonu. Bylo zji\u0161t\u011Bno, \u017Ee v\u011Bt\u0161ina vzork\u016F kontaminovan\u00FDch nivalenolem obsahuje t\u00E9\u017E jeho glykosylovanou formu a v\u0161echny vzorky obsahuj\u00EDc\u00ED zearalenon obsahuj\u00ED zn\u00E1m\u00FD zearalenon-sulf\u00E1t. Relativn\u00ED zastoupen\u00ED t\u011Bchto konjug\u00E1t\u016F bylo spo\u010Dteno ve vztahu k obsahu p\u016Fvodn\u00EDho mykotoxinu. Kros-reaktivita komer\u010Dn\u011B dostupn\u00FDch imunoafinitn\u00EDch kolonek dedikovan\u00FDch pro nivalenol (DON-NIV WB, Vicam) a zearalenon (Easi-Extract ZON, R-Biopharm a ZearalaTest WB, Vicam) v\u016F\u010Di t\u011Bmto konjugovan\u00FDm form\u00E1m mykotoxin\u016F nebyla prok\u00E1z\u00E1na."@cs . "Vep\u0159\u00EDkov\u00E1, Zdenka" . . "U-HPLC-HRMS; mycotoxin conjugates; nivalenol; zearalenone; Mycotoxins"@en . "D\u017Euman, Zbyn\u011Bk" . "5"^^ . "83283" . . . "Conjugated forms of Fusarium mycotoxins zearalenone and nivalenol in spring barley"@en . "5"^^ . . "22330" . "[F0240AB72647]" . "RIV/60461373:22330/13:43896674" . . . . . "2013-11-27+01:00"^^ . . . . . . "8"^^ . . "Zachari\u00E1\u0161ov\u00E1, Milena" . "Mendelova zem\u011Bd\u011Blsk\u00E1 a lesnick\u00E1 univerzita v Brn\u011B" . . "978-80-7375-912-4" . . "V\u00FDzkum, v\u00FDvoj a aplikace nov\u00FDch postup\u016F zam\u011B\u0159en\u00FDch na kontrolu a minimalizaci vlivu \u010Dinitel\u016F s negativn\u00EDm dopadem na zdravotn\u00ED bezpe\u010Dnost zem\u011Bd\u011Blsk\u00FDch surovin, produkt\u016F a potravin" . . . . "Konjugovan\u00E9 formy mykotoxin\u016F zearalenonu a nivalenolu v je\u010Dmeni jarn\u00EDm" . "RIV/60461373:22330/13:43896674!RIV14-MZE-22330___" . "Konjugovan\u00E9 formy mykotoxin\u016F zearalenonu a nivalenolu v je\u010Dmeni jarn\u00EDm" . . "Conjugated forms of Fusarium mycotoxins zearalenone and nivalenol in spring barley"@en . "Haj\u0161lov\u00E1, Jana" . "P(QI111B044), Z(MSM6046137305)" . "Brno" . "Konjugovan\u00E9 formy mykotoxin\u016F zearalenonu a nivalenolu v je\u010Dmeni jarn\u00EDm"@cs . "Brno" . "Mykotoxiny mohou b\u00FDt stejn\u011B jako ostatn\u00ED xenobiotika \u010D\u00E1ste\u010Dn\u011B metabolizov\u00E1ny za vzniku konjugovan\u00FDch forem mykotoxin\u016F. Konjugovan\u00E9 mykotoxiny se mohou vyskytovat bu\u010F ve form\u011B rozpustn\u00E9 (maskovan\u00E9 mykotoxiny) \u010Di asociovan\u00E9 v makromolekule (v\u00E1zan\u00E9 mykotoxiny). Konzumenti jsou tak prost\u0159ednictv\u00EDm potravin kontaminovan\u00FDch mykotoxiny vystaveni jak jejich nativn\u00EDm, tak \u010D\u00E1ste\u010Dn\u011B metabolizovan\u00FDm form\u00E1m. V r\u00E1mci projektu Ministerstva zem\u011Bd\u011Blstv\u00ED \u010CR QI111B044 Komplexn\u00ED strategie pro minimalizaci negativn\u00EDho dopadu infekce toxinogenn\u00EDmi houbami rodu Fusarium v obilovin\u00E1ch a odvozen\u00FDch produktech byly objeveny velmi vysok\u00E9 koncentrace mykotoxin\u016F nivalenolu a zearalenonu ve vzorc\u00EDch je\u010Dmene jarn\u00EDho p\u011Bstovan\u00FDch v lokalit\u00E1ch Krom\u011B\u0159\u00ED\u017E a Lib\u010Dany, dan\u00E9 vzorky byly pak analyzov\u00E1ny na v\u00FDskyt konjugovan\u00FDch forem t\u011Bchto sekund\u00E1rn\u00EDch metabolit\u016F. S vyu\u017Eit\u00EDm vysokorozli\u0161ovac\u00ED hmotnostn\u00ED spektrometrie byly sledov\u00E1ny mo\u017En\u00E9 konjug\u00E1ty nivalenolu a zearalenonu. Bylo zji\u0161t\u011Bno, \u017Ee v\u011Bt\u0161ina vzork\u016F kontaminovan\u00FDch nivalenolem obsahuje t\u00E9\u017E jeho glykosylovanou formu a v\u0161echny vzorky obsahuj\u00EDc\u00ED zearalenon obsahuj\u00ED zn\u00E1m\u00FD zearalenon-sulf\u00E1t. Relativn\u00ED zastoupen\u00ED t\u011Bchto konjug\u00E1t\u016F bylo spo\u010Dteno ve vztahu k obsahu p\u016Fvodn\u00EDho mykotoxinu. Kros-reaktivita komer\u010Dn\u011B dostupn\u00FDch imunoafinitn\u00EDch kolonek dedikovan\u00FDch pro nivalenol (DON-NIV WB, Vicam) a zearalenon (Easi-Extract ZON, R-Biopharm a ZearalaTest WB, Vicam) v\u016F\u010Di t\u011Bmto konjugovan\u00FDm form\u00E1m mykotoxin\u016F nebyla prok\u00E1z\u00E1na." . "Konjugovan\u00E9 formy mykotoxin\u016F zearalenonu a nivalenolu v je\u010Dmeni jarn\u00EDm"@cs . . "Mycotoxins can be partly metabolized as other xenobiotics to form conjugated forms of mycotoxins. Conjugated mycotoxins may occur either as soluble in water (masked mycotoxins) or associated in macromolecule (bound mycotoxins). Consumers of contaminated food or feed are therefore exposed to both native and also partly metabolized forms of mycotoxins. Very high levels of Fusarium mycotoxins nivalenol and zearalenone were found in a wide group of spring barley samples from localities Kromeriz and Libcany within the project of Ministry of Agriculture of the Czech Republic QI111B044 Comprehensive strategies to minimize the negative impact of Fusarium fungi infections in cereals and derived products. Contaminated samples were analyzed using ultra-high resolution mass spectrometry in order to detect conjugated forms of nivalenol and zearalenone. It was found that the most of the samples contaminated with nivalenol also contained its glycosylated form (nivalenol-glucoside) and the samples contaminated with zearalenone contained known zearalenone-sulfate. Relative amount of detected conjugates was calculated as a ratio of particular conjugate and native toxin. Cross-reactivity of commercially available immunoaffinity columns dedicated for nivalenol (DON-NIV WB, Vicam) and zearalenone (ZearalaTest WB, Vicam and Easi-Extract ZON, R-Biopharm) was not confirmed for nivalenol-glucoside and zearalenone-sulfate."@en . . . . "Slav\u00EDkov\u00E1, Petra" . .