. "Amides derived from heteroaromatic amines and selected steryl hemiesters"@en . . . . "Bildziukevich, Uladzimir" . "22330" . . "\u0160aman, David" . . . . "Cytotoxic activity; Amide; Lanosterol; Cholesterol; Heteroaromatic amine"@en . . "Amides derived from heteroaromatic amines and selected steryl hemiesters" . . . "Amides derived from heteroaromatic amines and selected steryl hemiesters"@en . "Dra\u0161ar, Pavel" . "Havl\u00ED\u010Dek, Libor" . . . . "R\u00E1rov\u00E1, Lucie" . "Amides derived from heteroaromatic amines and selected steryl hemiesters" . . "60231" . "78" . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "10.1016/j.steroids.2013.10.003" . "Steroids" . . "6"^^ . "3"^^ . . "The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M)."@en . "000328303300006" . . . "I, P(ED0007/01/01), P(GAP503/11/0616), Z(MSM6046137305)" . "14" . . . "RIV/60461373:22330/13:43895382" . "Wimmer, Zdenek" . "The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and hetero-aromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-Iymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3-5 and 7-10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-Iymphoblastic leukemia cell line. The compounds 8 and 9 displayed the reasonable cytotoxicity among this series of amides, tested on the cell lines of T-Iymphoblastic leukemia [14.5 +/- 0.4 mu M (8) and 18.5 +/- 3.9 mu M (9)], breast adenocarcinoma [19.5 +/- 2.1 mu M (8) and 23.1 +/- 4.0 mu M (9)] and cervical cancer [24.8 +/- 5.3 mu M (8) and 29.1 +/- 4.7 mu M (9)]. Only the compound 8 was adequately less active on normal human fibroblasts (40.4 +/- 11.1 mu M)." . "RIV/60461373:22330/13:43895382!RIV14-GA0-22330___" . . "0039-128X" . . "[CC3D39E7B4D7]" . "6"^^ . .