. . "Cyklick\u00E9 peptidy jako \u00FA\u010Dinn\u00E1 antibakteri\u00E1ln\u00ED l\u00E9\u010Diva"@cs . . "4"^^ . "Cyclic peptides as an effective antibacterial drugs"@en . "Antimicrobial peptides are substances commonly occurring in nature, they serve as defense agents against pathogens. Since the 80s of the last century, when the first short peptide with antimicrobial effect, cecropin, was isolated and characterized, they were investigated and proposed as suitable candidates to further fight against infectious diseases mainly caused by resistant strains of bacteria such as methicillin-resistant Staphylococcus aureus. Until now more than 1600 antimicrobial peptides were identified. Some of them are already used in industry and as an effective drug. This article is engaged in only one of many groups of antimicrobial peptides, cyclic peptides, which showed high activity against bacteria and are already commercially available or their use is contemplated and they are undergoing clinical trials."@en . "Antimikrobi\u00E1ln\u00ED peptidy jsou l\u00E1tky b\u011B\u017En\u011B se vyskytuj\u00EDc\u00ED v p\u0159\u00EDrod\u011B, kter\u00E9 slou\u017E\u00ED organism\u016Fm jako obrana proti patogen\u016Fm. Od 80. let minul\u00E9ho stolet\u00ED, kdy byl izolov\u00E1n a charakterizov\u00E1n prvn\u00ED kr\u00E1tk\u00FD peptid s antimikrobi\u00E1ln\u00EDmi \u00FA\u010Dinky cecropin, byly podrobn\u011B zkoum\u00E1ny a navr\u017Eeny jako vhodn\u00ED kandid\u00E1ti v dal\u0161\u00EDm boji proti infek\u010Dn\u00EDm chorob\u00E1m zp\u016Fsoben\u00FDm hlavn\u011B rezistentn\u00EDmi kmeny bakteri\u00ED, jako je nap\u0159\u00EDklad methicilin rezistentn\u00ED bakterie Staphylococcus aureus. Do sou\u010Dasnosti bylo identifikov\u00E1no v\u00EDce jak 1600 antimikrobi\u00E1ln\u00EDch peptid\u016F. N\u011Bkter\u00E9 z nich jsou ji\u017E vyu\u017E\u00EDv\u00E1ny v pr\u016Fmyslu i jako \u00FA\u010Dinn\u00E1 l\u00E9\u010Diva. Tento \u010Dl\u00E1nek se zab\u00FDv\u00E1 jen jednou z mnoha skupin antimikrobi\u00E1ln\u00EDch peptid\u016F, cyklick\u00FDmi peptidy, kter\u00E9 vykazuj\u00ED vysokou aktivitu proti bakteri\u00EDm a jsou ji\u017E komer\u010Dn\u011B vyu\u017E\u00EDv\u00E1ny nebo se o jejich vyu\u017Eit\u00ED uva\u017Euje a proch\u00E1zej\u00ED klinick\u00FDmi testy." . "therapeutic potential; host defense; peptide antibiotics; cyclic antimicrobial peptides"@en . "1210-1737" . . . "Bioprospect" . "CZ - \u010Cesk\u00E1 republika" . . "1"^^ . "Cyklick\u00E9 peptidy jako \u00FA\u010Dinn\u00E1 antibakteri\u00E1ln\u00ED l\u00E9\u010Diva" . . "1"^^ . "P(GA522/09/1693), P(GD305/09/H008), Z(MSM6046137305)" . "Mac\u016Frkov\u00E1, Anna" . "1" . . "[04DF1FF6DA33]" . "21" . . . . . "22330" . "Cyclic peptides as an effective antibacterial drugs"@en . . . . "RIV/60461373:22330/11:43892541!RIV12-MSM-22330___" . "RIV/60461373:22330/11:43892541" . "Antimikrobi\u00E1ln\u00ED peptidy jsou l\u00E1tky b\u011B\u017En\u011B se vyskytuj\u00EDc\u00ED v p\u0159\u00EDrod\u011B, kter\u00E9 slou\u017E\u00ED organism\u016Fm jako obrana proti patogen\u016Fm. Od 80. let minul\u00E9ho stolet\u00ED, kdy byl izolov\u00E1n a charakterizov\u00E1n prvn\u00ED kr\u00E1tk\u00FD peptid s antimikrobi\u00E1ln\u00EDmi \u00FA\u010Dinky cecropin, byly podrobn\u011B zkoum\u00E1ny a navr\u017Eeny jako vhodn\u00ED kandid\u00E1ti v dal\u0161\u00EDm boji proti infek\u010Dn\u00EDm chorob\u00E1m zp\u016Fsoben\u00FDm hlavn\u011B rezistentn\u00EDmi kmeny bakteri\u00ED, jako je nap\u0159\u00EDklad methicilin rezistentn\u00ED bakterie Staphylococcus aureus. Do sou\u010Dasnosti bylo identifikov\u00E1no v\u00EDce jak 1600 antimikrobi\u00E1ln\u00EDch peptid\u016F. N\u011Bkter\u00E9 z nich jsou ji\u017E vyu\u017E\u00EDv\u00E1ny v pr\u016Fmyslu i jako \u00FA\u010Dinn\u00E1 l\u00E9\u010Diva. Tento \u010Dl\u00E1nek se zab\u00FDv\u00E1 jen jednou z mnoha skupin antimikrobi\u00E1ln\u00EDch peptid\u016F, cyklick\u00FDmi peptidy, kter\u00E9 vykazuj\u00ED vysokou aktivitu proti bakteri\u00EDm a jsou ji\u017E komer\u010Dn\u011B vyu\u017E\u00EDv\u00E1ny nebo se o jejich vyu\u017Eit\u00ED uva\u017Euje a proch\u00E1zej\u00ED klinick\u00FDmi testy."@cs . "Cyklick\u00E9 peptidy jako \u00FA\u010Dinn\u00E1 antibakteri\u00E1ln\u00ED l\u00E9\u010Diva" . "Cyklick\u00E9 peptidy jako \u00FA\u010Dinn\u00E1 antibakteri\u00E1ln\u00ED l\u00E9\u010Diva"@cs . . "192596" . . . . .