"RIV/60461373:22310/13:43895356" . "10.3109/10837450.2013.788515" . . . "RIV/60461373:22310/13:43895356!RIV14-MSM-22310___" . "58862" . "Pharmaceutical Development and Technology" . . "Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuray and allow obtaining a lot of information about the original products. Scanning electron microscopy (SEM) is used for observation infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient." . . "surface; solid dosage form; scanning electron microscopy; microtome; FTIR mapping; Cut"@en . "A new way of solid dosage form samples preparation for SEM and FTIR using microtome"@en . . . "A new way of solid dosage form samples preparation for SEM and FTIR using microtome"@en . "3"^^ . "Gr\u00FCnwaldov\u00E1, Veronika" . "19" . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "A new way of solid dosage form samples preparation for SEM and FTIR using microtome" . . "[A78DDBD52B66]" . "Kratochv\u00EDl, Bohumil" . "2"^^ . . . "Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuray and allow obtaining a lot of information about the original products. Scanning electron microscopy (SEM) is used for observation infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient."@en . "6"^^ . . . . "Z(MSM6046137302)" . . "22310" . "A new way of solid dosage form samples preparation for SEM and FTIR using microtome" . . "\u0160imek, Michal" . . . . "1083-7450" . "4" . . . .