"Highly Efficient and Broad-Scope Protocol for the Preparation of 7-Substituted 6-Halopurines via N9-Boc-Protected 7,8-Dihydropurines" . "4" . . . "Highly Efficient and Broad-Scope Protocol for the Preparation of 7-Substituted 6-Halopurines via N9-Boc-Protected 7,8-Dihydropurines"@en . "[2B7E3932905E]" . "8"^^ . . "Synthesis" . "RIV/60461373:22310/12:43892738!RIV13-GA0-22310___" . "DE - Spolkov\u00E1 republika N\u011Bmecko" . "Highly Efficient and Broad-Scope Protocol for the Preparation of 7-Substituted 6-Halopurines via N9-Boc-Protected 7,8-Dihydropurines" . "44" . . "0039-7881" . . . . "RIV/60461373:22310/12:43892738" . . . . . "P(GA203/09/1552), P(LC06070), S" . . . . . . "139008" . "9-Boc-6-chloropurine, which can be obtained in high yield, is nearly quantitatively reduced with the THF?BH3 complex. The obtained 9-Boc-7,8-dihydropurine derivative is more stable compared to the corresponding 9-tritylpurine and can be smoothly N7-alkylated, acylated, or it can serve as an N-nucleophile in conjugate additions. Deprotection with trifluoroacetic acid followed by MnO2 oxidation affords the N7-substituted purines in high yields. The whole sequence of alkylation, deprotection, and oxidation can be done with crude intermediates using chromatography only for the purification of the final N7-substituted purine."@en . "reduction; nucleobases; Michael addition; acylation; alkylation"@en . "Dvo\u0159\u00E1k, Dalimil" . "3"^^ . "22310" . "3"^^ . . "10.1055/s-0031-1290068" . . . . "Kotek, Vladislav" . "9-Boc-6-chloropurine, which can be obtained in high yield, is nearly quantitatively reduced with the THF?BH3 complex. The obtained 9-Boc-7,8-dihydropurine derivative is more stable compared to the corresponding 9-tritylpurine and can be smoothly N7-alkylated, acylated, or it can serve as an N-nucleophile in conjugate additions. Deprotection with trifluoroacetic acid followed by MnO2 oxidation affords the N7-substituted purines in high yields. The whole sequence of alkylation, deprotection, and oxidation can be done with crude intermediates using chromatography only for the purification of the final N7-substituted purine." . "Tobrman, Tom\u00E1\u0161" . "Highly Efficient and Broad-Scope Protocol for the Preparation of 7-Substituted 6-Halopurines via N9-Boc-Protected 7,8-Dihydropurines"@en . . .